{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T14:07:11Z","timestamp":1767276431369,"version":"3.37.3"},"reference-count":42,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2018,6,17]],"date-time":"2018-06-17T00:00:00Z","timestamp":1529193600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2016M592825"],"award-info":[{"award-number":["2016M592825"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cellular Molecular Medi"],"published-print":{"date-parts":[[2018,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Myricitrin is a natural occurring flavonoid glycoside that possesses effects on inhibiting nitric oxide (<jats:styled-content style=\"fixed-case\">NO<\/jats:styled-content>) transmission and preventing inflammatory reaction. Although previous study showed the myricitrin possesses antibone loss effects via reducing the expression of <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20106 and partially suppressing reactive oxygen species (<jats:styled-content style=\"fixed-case\">ROS<\/jats:styled-content>) production. However, the effects of myricitrin on nuclear factor\u2010kappaB ligand (<jats:styled-content style=\"fixed-case\">RANKL<\/jats:styled-content>)\u2010stimulated osteoclastogenesis have not yet been further investigated. The current study was aimed to demonstrating the inhibitory effects of myricitrin on <jats:styled-content style=\"fixed-case\">RANKL<\/jats:styled-content>\u2010stimulated osteoclastogenesis and relevant mechanisms. We found myricitrin significantly suppressed osteoclastogenesis suggesting that it may acts on <jats:styled-content style=\"fixed-case\">RANKL<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">RANK<\/jats:styled-content> induced downstream signal cross cascading in osteoclast precursors. In that, our Western blotting results showed myricitrin significantly attenuated <jats:styled-content style=\"fixed-case\">RNAKL<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">MAPK<\/jats:styled-content>s (phosphorylation of p38, <jats:styled-content style=\"fixed-case\">ERK<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> JNK<\/jats:styled-content>) and <jats:styled-content style=\"fixed-case\">AKT<\/jats:styled-content> signal cascading. Complementing previous study, our results suggesting as a natural inhibitor, myricitrin possesses the potential therapeutic effects on inflammatory osteolysis.<\/jats:p>","DOI":"10.1111\/jcmm.13703","type":"journal-article","created":{"date-parts":[[2018,6,18]],"date-time":"2018-06-18T04:15:25Z","timestamp":1529295325000},"page":"4236-4242","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Inhibition effects of a natural inhibitor on <scp>RANKL<\/scp> downstream cellular signalling cascades cross\u2010talking"],"prefix":"10.1111","volume":"22","author":[{"given":"Biao","family":"Wang","sequence":"first","affiliation":[{"name":"Hong\u2010Hui Hospital Xi'an Jiaotong University College of Medicine Xi'an China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dingjun","family":"Hao","sequence":"additional","affiliation":[{"name":"Hong\u2010Hui Hospital Xi'an Jiaotong University College of Medicine Xi'an 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