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This study investigated whether bradykinin\u2010mediated Ca<jats:sup>2+<\/jats:sup> signalling participates in regulating cellular functions in cultured human cardiac c\u2010Kit<jats:sup>+<\/jats:sup> progenitor cells using laser scanning confocal microscopy and biochemical approaches. It was found that bradykinin increased cytosolic free Ca<jats:sup>2+<\/jats:sup> (<jats:inline-graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"graphic\/jcmm13706-math-0001.png\" xlink:title=\"urn:x-wiley:15821838:media:jcmm13706:jcmm13706-math-0001\"\/>) by triggering a transient Ca<jats:sup>2+<\/jats:sup> release from ER IP3Rs followed by sustained Ca<jats:sup>2+<\/jats:sup> influx through store\u2010operated Ca<jats:sup>2+<\/jats:sup> entry (SOCE) channel. Blockade of B2 receptor with HOE140 or IP3Rs with araguspongin B or silencing IP3R3 with siRNA abolished both Ca<jats:sup>2+<\/jats:sup> release and Ca<jats:sup>2+<\/jats:sup> influx. It is interesting to note that the bradykinin\u2010induced cell cycle progression and migration were not observed in cells with siRNA\u2010silenced IP3R3 or the SOCE component TRPC1, Orai1 or STIM1. Also the bradykinin\u2010induced increase in pAkt and pERK1\/2 as well as cyclin D1 was reduced in these cells. These results demonstrate for the first time that bradykinin\u2010mediated increase in free <jats:inline-graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"graphic\/jcmm13706-math-0002.png\" xlink:title=\"urn:x-wiley:15821838:media:jcmm13706:jcmm13706-math-0002\"\/> via ER\u2010IP3R3 Ca<jats:sup>2+<\/jats:sup> release followed by Ca<jats:sup>2+<\/jats:sup> influx through SOCE channel plays a crucial role in regulating cell growth and migration via activating pAkt, pERK1\/2 and cyclin D1 in human cardiac c\u2010Kit<jats:sup>+<\/jats:sup> progenitor cells.<\/jats:p>","DOI":"10.1111\/jcmm.13706","type":"journal-article","created":{"date-parts":[[2018,8,17]],"date-time":"2018-08-17T10:44:33Z","timestamp":1534502673000},"page":"4688-4699","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Bradykinin\u2010mediated Ca<sup>2+<\/sup> signalling regulates cell growth and mobility in human cardiac c\u2010Kit<sup>+<\/sup> progenitor cells"],"prefix":"10.1111","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3993-0315","authenticated-orcid":false,"given":"Gang","family":"Li","sequence":"first","affiliation":[{"name":"Xiamen Cardiovascular Hospital Xiamen University Xiamen Fujian China"},{"name":"Department of Medicine Li Ka Shing Faculty of Medicine University of Hong Kong Pokfulam Hong Kong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui","family":"Che","sequence":"additional","affiliation":[{"name":"Department of Medicine Li Ka Shing Faculty of Medicine University of Hong Kong Pokfulam Hong Kong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei\u2010Yin","family":"Wu","sequence":"additional","affiliation":[{"name":"Xiamen Cardiovascular Hospital Xiamen University Xiamen Fujian 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