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Traditional method to induce <jats:styled-content style=\"fixed-case\">MI<\/jats:styled-content> by left coronary artery (<jats:styled-content style=\"fixed-case\">LCA<\/jats:styled-content>) ligation is typically performed by an invasive approach that requires ventilation and thoracotomy, causing serious injuries in animals undergoing this surgery. We attempted to develop a minimally invasive method (<jats:styled-content style=\"fixed-case\">MIM<\/jats:styled-content>) to induce <jats:styled-content style=\"fixed-case\">MI<\/jats:styled-content> in mice. Under the guide of ultrasound, <jats:styled-content style=\"fixed-case\">LCA<\/jats:styled-content> ligation was performed in mice without ventilation and chest\u2010opening. Compared to sham mice, <jats:styled-content style=\"fixed-case\">MIM<\/jats:styled-content> induced <jats:styled-content style=\"fixed-case\">MI<\/jats:styled-content> in mice as determined by triphenyltetrazolium chloride staining and Masson staining. Mice with <jats:styled-content style=\"fixed-case\">MIM<\/jats:styled-content> surgery revealed the reductions of <jats:styled-content style=\"fixed-case\">LVEF<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> LVFS<\/jats:styled-content>, E\/A and ascending aorta (<jats:styled-content style=\"fixed-case\">AAO<\/jats:styled-content>) blood flow, and the elevations of S\u2010T segment and serum <jats:styled-content style=\"fixed-case\">cT<\/jats:styled-content>n\u2010I levels at 24 post\u2010operative hours. The effects of <jats:styled-content style=\"fixed-case\">MI<\/jats:styled-content> induced by <jats:styled-content style=\"fixed-case\">MIM<\/jats:styled-content> were comparable to the effects of <jats:styled-content style=\"fixed-case\">MI<\/jats:styled-content> produced by traditional method in mice. Importantly, <jats:styled-content style=\"fixed-case\">MIM<\/jats:styled-content> increased the survival rates and caused less inflammation after the surgery of <jats:styled-content style=\"fixed-case\">LCA<\/jats:styled-content> ligation, compared to the surgery of traditional method. Further, <jats:styled-content style=\"fixed-case\">MIM<\/jats:styled-content> induced angiogenesis and apoptosis in ischaemic hearts from mice at postoperative 28\u00a0days as similarly as traditional method did. Finally, the <jats:styled-content style=\"fixed-case\">MIM<\/jats:styled-content> model was able to develop into the myocardial ischaemia\/reperfusion model by using a balloon catheter with minor modifications. The <jats:styled-content style=\"fixed-case\">MI<\/jats:styled-content> model is able to be efficiently induced by a minimally invasive approach in mice without ventilation and chest\u2010opening. This new model is potentially to be used in studying ischaemia\u2010related heart diseases.<\/jats:p>","DOI":"10.1111\/jcmm.13708","type":"journal-article","created":{"date-parts":[[2018,9,16]],"date-time":"2018-09-16T09:47:43Z","timestamp":1537091263000},"page":"5208-5219","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["A minimally invasive approach to induce myocardial infarction in mice without thoracotomy"],"prefix":"10.1111","volume":"22","author":[{"given":"Quan","family":"Sun","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Medicine Xiangya Hospital Central South University Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9487-2376","authenticated-orcid":false,"given":"Kang\u2010Kai","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Pathophysiology Xiangya School of Medicine Central South 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