{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T02:18:24Z","timestamp":1789784304688,"version":"4.0.1"},"reference-count":69,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2018,7,4]],"date-time":"2018-07-04T00:00:00Z","timestamp":1530662400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01HL128173"],"award-info":[{"award-number":["R01HL128173"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005189","name":"Leukemia and Lymphoma Society","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005189","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cellular Molecular Medi"],"published-print":{"date-parts":[[2018,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Allogeneic stem cell transplantation is currently the only curative therapy for primary myelofibrosis (MF), while the JAK2 inhibitor, ruxolitinib. Has been approved only for palliation. Other therapies are desperately needed to reverse life\u2010threatening MF. However, the cell(s) and cytokine(s) that promote MF remain unclear. Several reports have demonstrated that captopril, an inhibitor of angiotensin\u2010converting enzyme that blocks the production of angiotensin II (Ang II), mitigates fibrosis in heart, lung, skin and kidney. Here, we show that captopril can mitigate the development of MF in the <jats:italic>Gata1<\/jats:italic><jats:sup><jats:italic>low<\/jats:italic><\/jats:sup> mouse model of primary MF. <jats:italic>Gata1<\/jats:italic><jats:sup><jats:italic>low<\/jats:italic><\/jats:sup> mice were treated with 79\u00a0mg\/kg\/d captopril in the drinking water from 10 to 12\u00a0months of age. At 13\u00a0months of age, bone marrows were examined for fibrosis, megakaryocytosis and collagen expression; spleens were examined for megakaryocytosis, splenomegaly and collagen expression. Treatment of <jats:italic>Gata1<\/jats:italic><jats:sup><jats:italic>low<\/jats:italic><\/jats:sup> mice with captopril in the drinking water was associated with normalization of the bone marrow cellularity; reduced reticulin fibres, splenomegaly and megakaryocytosis; and decreased collagen expression. Our findings suggest that treating with the ACE inhibitors captopril has a significant benefit in overcoming pathological changes associated with MF.<\/jats:p>","DOI":"10.1111\/jcmm.13710","type":"journal-article","created":{"date-parts":[[2018,7,4]],"date-time":"2018-07-04T08:26:45Z","timestamp":1530692805000},"page":"4274-4282","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Captopril mitigates splenomegaly and myelofibrosis in the <i>Gata1<\/i><sup><i>low<\/i><\/sup> murine model of myelofibrosis"],"prefix":"10.1111","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6704-4142","authenticated-orcid":false,"given":"Seth J.","family":"Corey","sequence":"first","affiliation":[{"name":"Division of Pediatric Hematology, Oncology &amp; Stem Cell Transplantation The Massey Cancer Center at Virginia Commonwealth University Richmond VA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jyoti","family":"Jha","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Molecular Therapeutics Uniformed Services University of the Health Sciences Bethesda MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth A.","family":"McCart","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Molecular Therapeutics Uniformed Services University of the Health Sciences Bethesda MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William B.","family":"Rittase","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Molecular Therapeutics Uniformed Services University of the Health Sciences Bethesda MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffy","family":"George","sequence":"additional","affiliation":[{"name":"Department of Microbiology Uniformed Services University of the Health Sciences Bethesda MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7412-9507","authenticated-orcid":false,"given":"Joseph J.","family":"Mattapallil","sequence":"additional","affiliation":[{"name":"Department of Microbiology Uniformed Services University of the Health Sciences Bethesda MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hrishikesh","family":"Mehta","sequence":"additional","affiliation":[{"name":"Division of Pediatric Hematology, Oncology &amp; Stem Cell Transplantation The Massey Cancer Center at Virginia Commonwealth University Richmond VA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mungunsukh","family":"Ognoon","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology Uniformed Services University of the Health Sciences Bethesda MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle A.","family":"Bylicky","sequence":"additional","affiliation":[{"name":"Neuroscience Graduate Program Uniformed Services University of the Health Sciences Bethesda MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas A.","family":"Summers","sequence":"additional","affiliation":[{"name":"Department of Pathology Uniformed Services University of the Health Sciences Bethesda MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Regina M.","family":"Day","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Molecular Therapeutics Uniformed Services University of the Health Sciences Bethesda MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,7,4]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2013-12-544411"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2015.233"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2016.148"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2017-04-742288"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2010.29.8711"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.2015-0094"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-05-091579"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V88.2.402.bloodjournal882402"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2015-11-679571"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)62056-1"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M602830200"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2011.04396.x"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.patbio.2004.02.008"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2002-06-1913"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1586\/ehm.09.17"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20160283"},{"key":"e_1_2_7_18_1","first-page":"34","article-title":"A novel interaction between megakaryocytes and activated fibrocytes increases TGF\u2010beta bioavailability in the Gata1(low) mouse model of myelofibrosis","volume":"5","author":"Zingariello M","year":"2015","journal-title":"Am J Blood Res"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.115.307495"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coph.2017.12.002"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0109763"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.15.2579"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1093\/jrr\/rrs004"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tcm.2017.12.006"},{"key":"e_1_2_7_25_1","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1097\/MCP.0000000000000349","article-title":"Radiation exposure and lung disease in today's nuclear world","volume":"23","author":"Deas SD","year":"2017","journal-title":"Curr Opin Pulm Med"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2016.03.019"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12072-016-9705-x"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exphem.2010.01.004"},{"key":"e_1_2_7_29_1","first-page":"30","article-title":"Stability of an aqueous formulation of captopril at 1\u00a0mg\/ml","volume":"29","author":"Escribano GMJ","year":"2005","journal-title":"Farm Hosp"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/his.12871"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/21.3.781"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2008.73"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/29.9.e45"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2017.00777"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1038\/bcj.2017.6"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-physiol-022516-034227"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1007\/s004180000235"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biocel.2011.11.019"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.1999.277.6.L1158"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1053\/hupa.2001.24321"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.1998.275.6.L1192"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00103.2001"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00595.2011"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semradonc.2006.11.010"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.171.1.346"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1995.183"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.1177\/153537020122601108"},{"key":"e_1_2_7_48_1","doi-asserted-by":"publisher","DOI":"10.2174\/138161207780618777"},{"key":"e_1_2_7_49_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1997.414"},{"key":"e_1_2_7_50_1","first-page":"118","article-title":"Angiotensin II type 1 receptor blocker inhibits pulmonary injury","volume":"28","author":"Mancini GB","year":"2005","journal-title":"Clin Invest Med"},{"key":"e_1_2_7_51_1","doi-asserted-by":"publisher","DOI":"10.1177\/1470320316628717"},{"key":"e_1_2_7_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2011.05.081"},{"key":"e_1_2_7_53_1","article-title":"Decreased risk of radiation pneumonitis with coincident concurrent use of angiotensin\u2010converting enzyme inhibitors in patients receiving lung stereotactic body radiation therapy","author":"Alite F","year":"2016","journal-title":"Am J Clin Oncol"},{"key":"e_1_2_7_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cllc.2015.08.007"},{"key":"e_1_2_7_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.prro.2015.07.003"},{"key":"e_1_2_7_56_1","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1097\/COC.0000000000000289","article-title":"Utility of the ACE inhibitor captopril in mitigating radiation\u2010associated pulmonary toxicity in lung cancer: results from nrg oncology RTOG 0123","volume":"41","author":"Small W","year":"2018","journal-title":"Am J Clin Oncol"},{"key":"e_1_2_7_57_1","doi-asserted-by":"publisher","DOI":"10.1124\/mol.113.091157"},{"key":"e_1_2_7_58_1","doi-asserted-by":"publisher","DOI":"10.1042\/CS20110660"},{"key":"e_1_2_7_59_1","doi-asserted-by":"publisher","DOI":"10.1124\/pr.112.006809"},{"key":"e_1_2_7_60_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.10-169433"},{"key":"e_1_2_7_61_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00280-002-0434-6"},{"key":"e_1_2_7_62_1","doi-asserted-by":"publisher","DOI":"10.1667\/RR14113.1"},{"key":"e_1_2_7_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2012.12.029"},{"key":"e_1_2_7_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exphem.2010.12.002"},{"key":"e_1_2_7_65_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2003-11-3828"},{"key":"e_1_2_7_66_1","doi-asserted-by":"publisher","DOI":"10.1634\/stemcells.18-4-287"},{"key":"e_1_2_7_67_1","doi-asserted-by":"publisher","DOI":"10.1038\/bcj.2017.51"},{"key":"e_1_2_7_68_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2013-02-482232"},{"key":"e_1_2_7_69_1","doi-asserted-by":"publisher","DOI":"10.4103\/0976-0105.177703"},{"key":"e_1_2_7_70_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-5173(99)00362-2"}],"container-title":["Journal of Cellular and Molecular Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjcmm.13710","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jcmm.13710","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jcmm.13710","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jcmm.13710","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,15]],"date-time":"2023-09-15T10:44:04Z","timestamp":1694774644000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jcmm.13710"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,7,4]]},"references-count":69,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2018,9]]}},"alternative-id":["10.1111\/jcmm.13710"],"URL":"https:\/\/doi.org\/10.1111\/jcmm.13710","archive":["Portico"],"relation":{},"ISSN":["1582-1838","1582-4934"],"issn-type":[{"value":"1582-1838","type":"print"},{"value":"1582-4934","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,7,4]]},"assertion":[{"value":"2018-03-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-05-05","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-07-04","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}