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To investigate whether endothelial progenitor cells (EPCs) participate in the restoration of hypoxia\u2010affected myocardium, we used a co\u2010culture model that allowed the intimate interaction between EPCs and myocardial slices, mimicking stem cell transplantation into the ischaemic heart. On this model, we showed that EPCs engrafted to some extent and only transiently survived into the host tissue, yet produced visible protective effects, in terms of angiogenesis and protection against apoptosis and identified miR\u2010377\u2010VE\u2010PTP axis as being involved in the protective effects of EPCs in hypoxic myocardium. We also showed that collagen, the main component of the myocardial scar, was important for these protective effects by preserving VE\u2010PTP levels, which were otherwise diminished by miR\u2010377. By this, a good face of the scar is revealed, which was so far perceived as having only detrimental impact on the exogenously delivered stem\/progenitor cells by affecting not only the engraftment, but also the general protective effects of stem cells.<\/jats:p>","DOI":"10.1111\/jcmm.13712","type":"journal-article","created":{"date-parts":[[2018,7,25]],"date-time":"2018-07-25T12:05:33Z","timestamp":1532520333000},"page":"4700-4708","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Collagen regulates the ability of endothelial progenitor cells to protect hypoxic myocardium through a mechanism involving miR\u2010377\/VE\u2010PTP axis"],"prefix":"10.1111","volume":"22","author":[{"given":"Ana\u2010Maria","family":"Rosca","sequence":"first","affiliation":[{"name":"Institute of Cellular Biology and Pathology \u201cNicolae Simionescu\u201d Bucharest 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