{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T20:46:08Z","timestamp":1761597968449,"version":"3.37.3"},"reference-count":38,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2018,7,25]],"date-time":"2018-07-25T00:00:00Z","timestamp":1532476800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81602269"],"award-info":[{"award-number":["81602269"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cellular Molecular Medi"],"published-print":{"date-parts":[[2018,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Ovarian cancer is the leading malignancy of the female reproductive system and is associated with inconspicuous early invasion and metastasis. We have previously reported that the oncogene <jats:styled-content style=\"fixed-case\">OTUB<\/jats:styled-content>1 plays a crucial role in ovarian cancer progression, but the role of its isoform, the non\u2010coding <jats:styled-content style=\"fixed-case\">RNA OTUB<\/jats:styled-content>1\u2010isoform2, in ovarian cancer is still elusive. Here, we reported that <jats:styled-content style=\"fixed-case\">OTUB<\/jats:styled-content>1\u2010isoform2 expression in ovarian cancer tissues was significantly higher than that in the paired paratumorous tissues (<jats:italic>P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>.01). The patients with high expression of <jats:styled-content style=\"fixed-case\">OTUB<\/jats:styled-content>1\u2010isoform2 had larger tumours than those with low expression (<jats:italic>P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>.05). The high expression of <jats:styled-content style=\"fixed-case\">OTUB<\/jats:styled-content>1\u2010isoform2 was correlated with the involvement of bilateral ovaries (<jats:italic>P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>.05), lymph node metastasis (<jats:italic>P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>.05), vascular invasion (<jats:italic>P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>.05), greater omentum involvement (<jats:italic>P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>.01), fallopian tube involvement (<jats:italic>P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>.05), advanced <jats:styled-content style=\"fixed-case\">FIGO<\/jats:styled-content> stages (<jats:italic>P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>.01) and recurrence (<jats:italic>P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>.01). Moreover, <jats:styled-content style=\"fixed-case\">OTUB<\/jats:styled-content>1\u2010isoform2 served as an independent negative prognostic predictor for disease\u2010free survival (<jats:styled-content style=\"fixed-case\">DFS<\/jats:styled-content>) and disease\u2010specific survival (<jats:styled-content style=\"fixed-case\">DSS<\/jats:styled-content>). Overexpression of <jats:styled-content style=\"fixed-case\">OTUB<\/jats:styled-content>1\u2010isoform2 in the ovarian cancer cells stimulated cell proliferation, migration and invasion both in\u00a0vitro and in\u00a0vivo. In summary, our study suggested that <jats:styled-content style=\"fixed-case\">OTUB<\/jats:styled-content>1\u2010isoform2 is a novel prognostic biomarker with independent oncogenic functions for ovarian cancer.<\/jats:p>","DOI":"10.1111\/jcmm.13733","type":"journal-article","created":{"date-parts":[[2018,7,25]],"date-time":"2018-07-25T12:38:48Z","timestamp":1532522328000},"page":"4794-4806","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["The non\u2010coding <scp>RNA OTUB<\/scp>1\u2010isoform2 promotes ovarian tumour progression and predicts poor prognosis"],"prefix":"10.1111","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5154-492X","authenticated-orcid":false,"given":"Shunni","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Pathology Obstetrics and Gynecology Hospital of Fudan University Shanghai 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