{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T18:09:40Z","timestamp":1789150180714,"version":"build-2803163510"},"reference-count":32,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2018,7,16]],"date-time":"2018-07-16T00:00:00Z","timestamp":1531699200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004731","name":"Natural Science Foundation of Zhejiang Province","doi-asserted-by":"publisher","award":["LQ16H160013"],"award-info":[{"award-number":["LQ16H160013"]}],"id":[{"id":"10.13039\/501100004731","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81572126"],"award-info":[{"award-number":["81572126"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cellular Molecular Medi"],"published-print":{"date-parts":[[2018,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Osteoclasts (\n                    <jats:styled-content style=\"fixed-case\">OC<\/jats:styled-content>\n                    ) are critical cells responsible for many bone diseases such as osteoporosis. It is of great interest to identify agents that can regulate the activity of\n                    <jats:styled-content style=\"fixed-case\">OC<\/jats:styled-content>\n                    to treat osteolytic bone diseases. In this study, we found that baicalin exerted a two\u2010way regulatory effect on\n                    <jats:styled-content style=\"fixed-case\">OC<\/jats:styled-content>\n                    in a concentration\u2010dependent manner in\u00a0vitro and in\u00a0vivo. In detail, baicalin at a low concentration (below 1\u00a0\u03bcmol\/L) enhanced\n                    <jats:styled-content style=\"fixed-case\">OC<\/jats:styled-content>\n                    differentiation and bone resorption, but baicalin at a high concentration (above 2\u00a0\u03bcmol\/L) exhibited inhibitory effects on\n                    <jats:styled-content style=\"fixed-case\">OC<\/jats:styled-content>\n                    . We demonstrated that baicalin at low concentrations enhanced the mitogen\u2010activated protein kinase (\n                    <jats:styled-content style=\"fixed-case\">MAPK<\/jats:styled-content>\n                    ) (\n                    <jats:styled-content style=\"fixed-case\">ERK<\/jats:styled-content>\n                    ) signalling pathway and activated c\u2010Fos and\n                    <jats:styled-content style=\"fixed-case\">NFAT<\/jats:styled-content>\n                    c1 expression, and thus enhanced gene expression,\n                    <jats:styled-content style=\"fixed-case\">OC<\/jats:styled-content>\n                    differentiation and bone resorption. However, baicalin at higher levels not only suppressed\n                    <jats:styled-content style=\"fixed-case\">ERK<\/jats:styled-content>\n                    phosphorylation and c\u2010fos and\n                    <jats:styled-content style=\"fixed-case\">NFAT<\/jats:styled-content>\n                    c1 expression, but also altered the expression of apoptosis\u2010related proteins, and therefore inhibiting\n                    <jats:styled-content style=\"fixed-case\">OC<\/jats:styled-content>\n                    function. This dual effect was further verified in an\n                    <jats:styled-content style=\"fixed-case\">LPS<\/jats:styled-content>\n                    \u2010induced mouse calvarial osteolysis model, evidenced by enhanced osteolysis at a lower concentration but reduced bone loss at a higher concentration. Overall, our findings indicate that baicalin exerts dose\u2010dependent effects on\n                    <jats:styled-content style=\"fixed-case\">OC<\/jats:styled-content>\n                    formation and function. Therefore, caution should be applied when using baicalin to treating\n                    <jats:styled-content style=\"fixed-case\">OC<\/jats:styled-content>\n                    \u2010related bone diseases.\n                  <\/jats:p>","DOI":"10.1111\/jcmm.13785","type":"journal-article","created":{"date-parts":[[2018,7,16]],"date-time":"2018-07-16T06:39:51Z","timestamp":1531723191000},"page":"5029-5039","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Dual effects of baicalin on osteoclast differentiation and bone resorption"],"prefix":"10.1111","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9495-4857","authenticated-orcid":false,"given":"Xuanyuan","family":"Lu","sequence":"first","affiliation":[{"name":"Department of Orthopaedics Shaoxing People's Hospital (Shaoxing Hospital, Zhejiang University School of Medicine) Shaoxing Zhejiang 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