{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T15:29:15Z","timestamp":1767713355574,"version":"3.37.3"},"reference-count":14,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2018,7,18]],"date-time":"2018-07-18T00:00:00Z","timestamp":1531872000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003710","name":"Korea Health Industry Development Institute","doi-asserted-by":"publisher","award":["HI14C1135","HI15C0987"],"award-info":[{"award-number":["HI14C1135","HI15C0987"]}],"id":[{"id":"10.13039\/501100003710","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cellular Molecular Medi"],"published-print":{"date-parts":[[2018,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Mesenchymal stem cells (<jats:styled-content style=\"fixed-case\">MSC<\/jats:styled-content>s) have been investigated to treat liver diseases, but the efficiency of <jats:styled-content style=\"fixed-case\">MSC<\/jats:styled-content>s to treat chronic liver diseases is conflicting. <jats:styled-content style=\"fixed-case\">FGF<\/jats:styled-content>21 can reduce inflammation and fibrosis. We established <jats:styled-content style=\"fixed-case\">FGF<\/jats:styled-content>21\u2010secreting adipose derived stem cells (<jats:styled-content style=\"fixed-case\">FGF<\/jats:styled-content>21_<jats:styled-content style=\"fixed-case\">ADSC<\/jats:styled-content>s) to enhance the effects of <jats:styled-content style=\"fixed-case\">ADSC<\/jats:styled-content>s and transplanted them into thioacetamide (<jats:styled-content style=\"fixed-case\">TAA<\/jats:styled-content>)\u2010induced liver fibrosis mice via the tail vein. Transplantation of <jats:styled-content style=\"fixed-case\">FGF<\/jats:styled-content>21_<jats:styled-content style=\"fixed-case\">ADSC<\/jats:styled-content>s significantly improved liver fibrosis by decreasing serum hyaluronic acid and reducing the expression of fibrosis\u2010related factors such as \u03b1\u2010smooth muscle actin (\u03b1\u2010<jats:styled-content style=\"fixed-case\">SMA<\/jats:styled-content>), collagen and tissue inhibitor of metalloproteinase\u20101 (<jats:styled-content style=\"fixed-case\">TIMP<\/jats:styled-content>\u20101) compared with the Empty_<jats:styled-content style=\"fixed-case\">ADSC<\/jats:styled-content>s by inhibition of p\u2010<jats:styled-content style=\"fixed-case\">JNK<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> NF<\/jats:styled-content>\u2010\u03baB and p\u2010Smad2\/3 signalling. \u03b1\u2010lactoalbumin (<jats:styled-content style=\"fixed-case\">LA<\/jats:styled-content>) and lactotransferrin (<jats:styled-content style=\"fixed-case\">LTF<\/jats:styled-content>), secretory factors produced from <jats:styled-content style=\"fixed-case\">FGF<\/jats:styled-content>21_<jats:styled-content style=\"fixed-case\">ADSC<\/jats:styled-content>s inhibited <jats:styled-content style=\"fixed-case\">TGF<\/jats:styled-content>\u2010\u03b21\u2010induced expression of \u03b1\u2010<jats:styled-content style=\"fixed-case\">SMA<\/jats:styled-content> and collagen in <jats:styled-content style=\"fixed-case\">LX<\/jats:styled-content>\u20102 cells. These results suggest that transplantation of <jats:styled-content style=\"fixed-case\">FGF<\/jats:styled-content>21_<jats:styled-content style=\"fixed-case\">ADSC<\/jats:styled-content>s inhibited liver fibrosis more effectively than Empty_<jats:styled-content style=\"fixed-case\">ADSC<\/jats:styled-content>s, possibly via secretion of \u03b1\u2010<jats:styled-content style=\"fixed-case\">LA<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">LTF<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/jcmm.13795","type":"journal-article","created":{"date-parts":[[2018,7,19]],"date-time":"2018-07-19T06:05:07Z","timestamp":1531980307000},"page":"5165-5169","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Effects of <scp>FGF<\/scp>21\u2010secreting adipose\u2010derived stem cells in thioacetamide\u2010induced hepatic fibrosis"],"prefix":"10.1111","volume":"22","author":[{"given":"Hwansu","family":"Kang","sequence":"first","affiliation":[{"name":"College of Pharmacy and Gachon Institute of Pharmaceutical Science Gachon University Incheon Korea"},{"name":"Lee Gil Ya Cancer and Diabetes Institute Gachon University Incheon Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eunhui","family":"Seo","sequence":"additional","affiliation":[{"name":"College of Pharmacy and Gachon Institute of Pharmaceutical Science Gachon University Incheon Korea"},{"name":"Lee Gil Ya Cancer and Diabetes Institute Gachon University Incheon Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jong\u2010Moon","family":"Park","sequence":"additional","affiliation":[{"name":"College of Pharmacy and Gachon Institute of Pharmaceutical Science Gachon University Incheon 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