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Schistosomiasis is one of the pathogenic factors which could induce hepatic fibrosis. Previous studies have shown that recombinant <jats:italic>Schistosoma japonicum<\/jats:italic> egg antigen P40 (<jats:styled-content style=\"fixed-case\">rSjP<\/jats:styled-content>40) can inhibit the activation and proliferation of <jats:styled-content style=\"fixed-case\">HSC<\/jats:styled-content>s. Micro<jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content>\u2010155 is one of the multifunctional noncoding <jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content>, which is involved in a series of important biological processes including cell development, proliferation, differentiation and apoptosis. Here, we try to observe the role of micro<jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content>\u2010155 in <jats:styled-content style=\"fixed-case\">rSjP<\/jats:styled-content>40\u2010inhibited <jats:styled-content style=\"fixed-case\">HSC<\/jats:styled-content> activation and explore its potential mechanisms. We found that micro<jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content>\u2010155 was raised in <jats:styled-content style=\"fixed-case\">rSjP<\/jats:styled-content>40\u2010treated <jats:styled-content style=\"fixed-case\">HSC<\/jats:styled-content>s, and further studies have shown that <jats:styled-content style=\"fixed-case\">rSjP<\/jats:styled-content>40 enhanced micro<jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content>\u2010155 expression by inhibiting <jats:styled-content style=\"fixed-case\">STAT<\/jats:styled-content>5 transcription. Up\u2010regulated micro<jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content>\u2010155 can down\u2010regulate the expression of <jats:styled-content style=\"fixed-case\">FOXO<\/jats:styled-content>3a and then participate in <jats:styled-content style=\"fixed-case\">rSjP<\/jats:styled-content>40\u2010inhibited expression of \u03b1\u2010smooth muscle actin (\u03b1\u2010<jats:styled-content style=\"fixed-case\">SMA<\/jats:styled-content>) and collagen I. Furthermore, we observed micro<jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content>\u2010155 inhibitor could partially restore the down\u2010regulation of <jats:styled-content style=\"fixed-case\">FOXO<\/jats:styled-content>3a, \u03b1\u2010<jats:styled-content style=\"fixed-case\">SMA<\/jats:styled-content> and collagen I expression in <jats:styled-content style=\"fixed-case\">LX<\/jats:styled-content>\u20102 cells induced by <jats:styled-content style=\"fixed-case\">rSjP<\/jats:styled-content>40. Therefore, our research provides further insight into the mechanism by which <jats:styled-content style=\"fixed-case\">rSjP<\/jats:styled-content>40 could inhibit HSC activation via miR\u2010155.<\/jats:p>","DOI":"10.1111\/jcmm.13819","type":"journal-article","created":{"date-parts":[[2018,8,9]],"date-time":"2018-08-09T12:53:58Z","timestamp":1533819238000},"page":"5486-5493","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["<scp>rSjP<\/scp>40 suppresses hepatic stellate cell activation by promoting micro<scp>RNA<\/scp>\u2010155 expression and inhibiting <scp>STAT<\/scp>5 and <scp>FOXO<\/scp>3a expression"],"prefix":"10.1111","volume":"22","author":[{"given":"Dandan","family":"Zhu","sequence":"first","affiliation":[{"name":"Department of Pathogen Biology School of Medicine Nantong University Nantong 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