{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T04:02:29Z","timestamp":1780372949707,"version":"3.54.1"},"reference-count":15,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2018,8,22]],"date-time":"2018-08-22T00:00:00Z","timestamp":1534896000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100007686","name":"Instituto Nacional de Perinatolog\u00eda","doi-asserted-by":"publisher","award":["212250\u20103210091"],"award-info":[{"award-number":["212250\u20103210091"]}],"id":[{"id":"10.13039\/501100007686","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cellular Molecular Medi"],"published-print":{"date-parts":[[2018,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The extracellular heat shock proteins (<jats:styled-content style=\"fixed-case\">eH<\/jats:styled-content>sp) family act as molecular chaperones regulating folding, transporting protein and are associated with immune modulation in different physiological and pathological processes. They have been localized in different gestational tissues and their concentration in amniotic fluid and serum has been determined. In the present study, we proposed to determine the concentration of <jats:styled-content style=\"fixed-case\">eH<\/jats:styled-content>sp\u201060, \u201070, <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20101\u03b2 and <jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content>\u03b1 in the serum of pregnant patients with 34 weeks of gestation with and without clinical evidences of preeclampsia (<jats:styled-content style=\"fixed-case\">PE<\/jats:styled-content>). Our results indicate significant increase of these markers in patients with <jats:styled-content style=\"fixed-case\">PE<\/jats:styled-content> with respect to healthy pregnant patients without active labor. Finally, the concentration of <jats:styled-content style=\"fixed-case\">eH<\/jats:styled-content>sp\u201060 and \u201070 correlated positively with the hepatic dysfunction markers uric acid, lactate dehydrogenase (<jats:styled-content style=\"fixed-case\">LDH<\/jats:styled-content>), glutamic oxaloacetic transaminase (GOT) glutamic pyruvic transaminase (GPT), and inflammatory <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20101\u03b2 and <jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content>\u03b1 response. In conclusion, our results demonstrate a strong associated between Hsp and marker of hepatic dysfunction.<\/jats:p>","DOI":"10.1111\/jcmm.13824","type":"journal-article","created":{"date-parts":[[2018,8,22]],"date-time":"2018-08-22T17:45:45Z","timestamp":1534959945000},"page":"5748-5752","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Secretion of heat shock \u201060, \u201070 kD protein, <scp>IL<\/scp>\u20101\u03b2 and <scp>TNF<\/scp>\u03b1 levels in serum of a term normal pregnancy and patients with pre\u2010eclampsia development"],"prefix":"10.1111","volume":"22","author":[{"given":"Mar\u00eda C.","family":"\u00c1lvarez\u2010Cabrera","sequence":"first","affiliation":[{"name":"Departamento de Inmunobioqu\u00edmica Instituto Nacional de Perinatolog\u00eda \u201cIsidro Espinosa de los Reyes\u201d (INPerIER) Ciudad de M\u00e9xico M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edgar","family":"Barrientos\u2010Galeana","sequence":"additional","affiliation":[{"name":"Departamento de Inmunobioqu\u00edmica Instituto Nacional de Perinatolog\u00eda \u201cIsidro Espinosa de los Reyes\u201d (INPerIER) Ciudad de M\u00e9xico M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asyadette","family":"Barrera\u2010Garc\u00eda","sequence":"additional","affiliation":[{"name":"Departamento de Tococirug\u00eda INPerIER Ciudad de M\u00e9xico M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mauricio","family":"Osorio\u2010Caballero","sequence":"additional","affiliation":[{"name":"Departamento de Salud Sexual y Reproductiva INPerIER Ciudad de M\u00e9xico M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jes\u00fas F.","family":"Acevedo","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology University of Texas Southwestern Medical Center Dallas Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oscar","family":"Flores\u2010Herrera","sequence":"additional","affiliation":[{"name":"Departamento de Bioqu\u00edmica, Facultad de Medicina Universidad Nacional Aut\u00f3noma de M\u00e9xico Ciudad de M\u00e9xico M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N\u00e9stor F.","family":"D\u00edaz","sequence":"additional","affiliation":[{"name":"Departamento de Fisiolog\u00eda y Desarrollo Celular INPerIER Ciudad de M\u00e9xico M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anayans\u00ed","family":"Molina\u2010Hern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Departamento de Fisiolog\u00eda y Desarrollo Celular INPerIER Ciudad de M\u00e9xico M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guadalupe","family":"Garc\u00eda\u2010L\u00f3pez","sequence":"additional","affiliation":[{"name":"Departamento de Fisiolog\u00eda y Desarrollo Celular INPerIER Ciudad de M\u00e9xico M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7604-6158","authenticated-orcid":false,"given":"H\u00e9ctor","family":"Flores\u2010Herrera","sequence":"additional","affiliation":[{"name":"Departamento de Inmunobioqu\u00edmica Instituto Nacional de Perinatolog\u00eda \u201cIsidro Espinosa de los Reyes\u201d (INPerIER) Ciudad de M\u00e9xico M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,8,22]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10753-013-9619-x"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)02800-2"},{"issue":"53","key":"e_1_2_7_4_1","first-page":"e1","article-title":"Gestational angiogenic biomarker patterns in high risk preeclampsia groups","volume":"209","author":"Maynard SE","year":"2013","journal-title":"Am J Obstet Gynecol"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M111.307579"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jri.2006.12.002"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1080\/14767050802054550"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12192-008-0067-8"},{"key":"e_1_2_7_9_1","first-page":"1122","article-title":"Hypertension in pregnancy. 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