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In OA, this balance is disrupted which results in cartilage degradation involving a plethora of inflammatory factors. Here, we identify a novel gene \u201cScm\u2010like with four MBT domains protein 2\u201d (SFMBT2) negatively regulated in OA cartilage. Articular cartilage from human OA patients undergoing knee arthroplasty surgery exhibited significantly decreased levels of SFMBT2 compared to the normal controls. Down\u2010regulation of SFMBT2 by specific siRNA disturbed the metabolic homoeostasis and led to decreased expression of anabolic genes (SOX9, COL2A1) while increasing the expression of catabolic genes (MMP13 and ADAMTS4), in human chondrocytes. Finally, we revealed that SFMBT2 intervention by siRNA contributed to the catabolic phenotype of human chondrocytes mediated by NF\u2010kB pathway.<\/jats:p>","DOI":"10.1111\/jcmm.13826","type":"journal-article","created":{"date-parts":[[2018,8,22]],"date-time":"2018-08-22T17:07:54Z","timestamp":1534957674000},"page":"5753-5758","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Down\u2010regulated in OA cartilage, SFMBT2 contributes to NF\u2010\u03baB\u2010mediated ECM degradation"],"prefix":"10.1111","volume":"22","author":[{"given":"Safdar","family":"Hussain","sequence":"first","affiliation":[{"name":"Department of Biochemistry and Molecular Biology School of Basic Medical Sciences Health Science Center Xi'an Jiaotong University Xi'an China"},{"name":"Centre for Applied Molecular Biology (CAMB) University of the Punjab Lahore 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