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Somatostatin analogues (<jats:styled-content style=\"fixed-case\">SSA<\/jats:styled-content>s) represent the primary medical therapy for acromegaly and are currently used as first\u2010line treatment or as second\u2010line therapy after unsuccessful pituitary surgery. However, a considerable proportion of patients do not adequately respond to <jats:styled-content style=\"fixed-case\">SSA<\/jats:styled-content>s treatment, and therefore, there is an urgent need to identify biomarkers predictors of response to <jats:styled-content style=\"fixed-case\">SSA<\/jats:styled-content>s. The aim of this study was to examine E\u2010cadherin expression by immunohistochemistry in fifty\u2010five <jats:styled-content style=\"fixed-case\">GH<\/jats:styled-content>\u2010producing pituitary tumours and determine the potential association with response to <jats:styled-content style=\"fixed-case\">SSA<\/jats:styled-content>s as well as other clinical and histopathological features. Acromegaly patients with tumours expressing low E\u2010cadherin levels exhibit a worse response to <jats:styled-content style=\"fixed-case\">SSA<\/jats:styled-content>s. E\u2010cadherin levels are associated with <jats:styled-content style=\"fixed-case\">GH<\/jats:styled-content>\u2010producing tumour histological subtypes. Our results indicate that the immunohistochemical detection of E\u2010cadherin might be useful in categorizing acromegaly patients based on the response to <jats:styled-content style=\"fixed-case\">SSA<\/jats:styled-content>s.<\/jats:p>","DOI":"10.1111\/jcmm.13851","type":"journal-article","created":{"date-parts":[[2019,3,7]],"date-time":"2019-03-07T05:12:00Z","timestamp":1551935520000},"page":"3088-3096","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":46,"title":["E\u2010cadherin expression is associated with somatostatin analogue response in acromegaly"],"prefix":"10.1111","volume":"23","author":[{"given":"Eva","family":"Venegas\u2010Moreno","sequence":"first","affiliation":[{"name":"Unidad de Gesti\u00f3n de Endocrinolog\u00eda y Nutrici\u00f3n Instituto de Biomedicina de Sevilla (IBiS) Hospital Universitario Virgen del Roc\u00edo\/CSIC\/Universidad de Sevilla Sevilla 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