{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,31]],"date-time":"2026-01-31T05:55:49Z","timestamp":1769838949874,"version":"3.49.0"},"reference-count":15,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2018,9,6]],"date-time":"2018-09-06T00:00:00Z","timestamp":1536192000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004281","name":"Narodowe Centrum Nauki","doi-asserted-by":"publisher","award":["2014\/13\/N\/NZ5\/01389"],"award-info":[{"award-number":["2014\/13\/N\/NZ5\/01389"]}],"id":[{"id":"10.13039\/501100004281","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cellular Molecular Medi"],"published-print":{"date-parts":[[2018,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The blood platelets are multifunctional blood cells which are involved in the initiation of atheroma, endothelial dysfunction, and modulation of inflammatory and immune responses in the pathophysiology of many diseases. Because of their multifaceted pro\u2010inflammatory activity, platelets may be involved in the pathogenesis of autoimmune thyroid diseases (<jats:styled-content style=\"fixed-case\">AITD<\/jats:styled-content>s), such as Hashimoto's thyroiditis and Graves' disease. The aim of this study was to assess the level of activation and response ability of platelets in <jats:styled-content style=\"fixed-case\">AITD<\/jats:styled-content>s. We used the flow cytometry technique and kinetic measurement of aggregation to analyse platelet function immediately after blood collection and to demonstrate their activation in the circulation of patients with <jats:styled-content style=\"fixed-case\">AITD<\/jats:styled-content>s. We noted reorganization of platelet subpopulations (normal platelets, microparticles and aggregates) in <jats:styled-content style=\"fixed-case\">AITD<\/jats:styled-content>s, dependent on the degree of cell activation. We proved the elevated expression of the active form of integrin receptor <jats:styled-content style=\"fixed-case\">GPII<\/jats:styled-content>b\/<jats:styled-content style=\"fixed-case\">III<\/jats:styled-content>a, responsible for platelet aggregation, and in the kinetic test we confirmed the increased aggregation of platelets in different intracellular signal pathways (dependent on <jats:styled-content style=\"fixed-case\">ADP<\/jats:styled-content>, collagen, arachidonic acid). Our study demonstrates the high platelet activation level found in <jats:styled-content style=\"fixed-case\">AITD<\/jats:styled-content>s.<\/jats:p>","DOI":"10.1111\/jcmm.13862","type":"journal-article","created":{"date-parts":[[2018,9,6]],"date-time":"2018-09-06T12:44:18Z","timestamp":1536237858000},"page":"6386-6390","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["The potential contribution and role of a blood platelets in autoimmune thyroid diseases"],"prefix":"10.1111","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9160-5464","authenticated-orcid":false,"given":"Ma\u0142gorzata","family":"Tomczy\u0144ska","sequence":"first","affiliation":[{"name":"Department of General Biochemistry Faculty of Biology and Environmental Protection University of Lodz Lodz Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ireneusz","family":"Salata","sequence":"additional","affiliation":[{"name":"Multi\u2010Med Plus' Medical Centre in Lodz Lodz Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7838-4097","authenticated-orcid":false,"given":"Micha\u0142","family":"Bijak","sequence":"additional","affiliation":[{"name":"Department of General Biochemistry Faculty of Biology and Environmental Protection University of Lodz Lodz Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joanna","family":"Saluk\u2010Bijak","sequence":"additional","affiliation":[{"name":"Department of General Biochemistry Faculty of Biology and Environmental Protection University of Lodz Lodz Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,9,6]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0609.2004.00341.x"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-007-0550-0"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.4065\/81.4.566-a"},{"key":"e_1_2_9_5_1","first-page":"1","article-title":"The role of platelets in antiphospholipid syndrome","volume":"7","author":"Baroni G","year":"2017","journal-title":"Platelets"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11010-017-2955-7"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1160\/th15-07-0598"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1160\/TH15-06-0477"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1160\/TH14-05-0455"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0090523"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2249.1998.00677.x"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/emmm.201201846"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/sji.12068"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1186\/ar2833"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.34381"},{"key":"e_1_2_9_16_1","first-page":"124","article-title":"Flow cytometric investigation of classical and alternative platelet activation markers","volume":"4","author":"Nagy JR","year":"2012","journal-title":"EJIFCC"}],"container-title":["Journal of Cellular and Molecular Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjcmm.13862","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jcmm.13862","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,15]],"date-time":"2023-09-15T02:22:51Z","timestamp":1694744571000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jcmm.13862"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,9,6]]},"references-count":15,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2018,12]]}},"alternative-id":["10.1111\/jcmm.13862"],"URL":"https:\/\/doi.org\/10.1111\/jcmm.13862","archive":["Portico"],"relation":{},"ISSN":["1582-1838","1582-4934"],"issn-type":[{"value":"1582-1838","type":"print"},{"value":"1582-4934","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,9,6]]},"assertion":[{"value":"2017-11-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-07-20","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-09-06","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}