{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T21:54:38Z","timestamp":1783461278828,"version":"3.55.0"},"reference-count":45,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2018,9,6]],"date-time":"2018-09-06T00:00:00Z","timestamp":1536192000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["NRF\u20102015R1D1A1A01056798"],"award-info":[{"award-number":["NRF\u20102015R1D1A1A01056798"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["NRF\u20102018R1D1A1B07047213"],"award-info":[{"award-number":["NRF\u20102018R1D1A1B07047213"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cellular Molecular Medi"],"published-print":{"date-parts":[[2018,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We previously reported that gentisic acid (2,5\u2010dihydroxybenzoic acid) is the third most abundant phenolic component of <jats:italic>Dendropanax morbifera<\/jats:italic> branch extracts. Here, we investigated its effects on cardiac hypertrophy and fibrosis in a mouse model of pressure overload and compared them to those of the beta blocker bisoprolol and calcium channel blocker diltiazem. Cardiac hypertrophy was induced in mice by transverse aortic constriction (<jats:styled-content style=\"fixed-case\">TAC<\/jats:styled-content>). Beginning 2\u00a0weeks after this procedure, the mice were given daily intraperitoneal injections of gentisic acid (100\u00a0mg\/kg\/d), bisoprolol (5\u00a0mg\/kg\/d) or diltiazem (10\u00a0mg\/kg\/d) for 3\u00a0weeks. Cardiac hypertrophy was evaluated by the heart weight\u2010to\u2010body weight ratio, the cardiomyocyte cross\u2010sectional area after haematoxylin and eosin staining, and echocardiography. Markers of cardiac hypertrophy and fibrosis were tested by reverse transcription\u2010quantitative real\u2010time polymerase chain reaction, western blotting and Masson's trichrome staining. The suppressive effects of gentisic acid treatment on <jats:styled-content style=\"fixed-case\">TAC<\/jats:styled-content>\u2010induced cardiac hypertrophy and fibrosis were comparable to those of bisoprolol administration. Cardiac hypertrophy was reversed and left ventricular septum and posterior wall thickness were restored by gentisic acid, bisoprolol and diltiazem treatment. Cardiac hypertrophic marker gene expression and atrial and brain natriuretic peptide levels were decreased by gentisic acid and bisoprolol, as were cardiac (interstitial and perivascular) fibrosis and fibrosis\u2010related gene expression. Cardiac hypertrophy\u2010associated upregulation of the transcription factors <jats:styled-content style=\"fixed-case\">GATA<\/jats:styled-content>4 and Sp1 and activation of extracellular signal\u2010regulated kinase 1\/2 were also negated by these drugs. These results suggest that gentisic acid could serve as a therapeutic agent for cardiac hypertrophy and fibrosis.<\/jats:p>","DOI":"10.1111\/jcmm.13869","type":"journal-article","created":{"date-parts":[[2018,9,6]],"date-time":"2018-09-06T14:04:18Z","timestamp":1536242658000},"page":"5964-5977","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Gentisic acid attenuates pressure overload\u2010induced cardiac hypertrophy and fibrosis in mice through inhibition of the <scp>ERK<\/scp>1\/2 pathway"],"prefix":"10.1111","volume":"22","author":[{"given":"Simei","family":"Sun","sequence":"first","affiliation":[{"name":"Heart Research Center Chonnam National University Hospital Gwangju Korea"},{"name":"Hypertension Heart Failure Research Center Chonnam National University Hospital Gwangju Korea"},{"name":"Molecular Medicine Brain Korea 21 PLUS Chonnam National University Graduate School Gwangju 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