{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T06:07:21Z","timestamp":1787551641798,"version":"build-2736575974"},"reference-count":44,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2018,10,16]],"date-time":"2018-10-16T00:00:00Z","timestamp":1539648000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31370379"],"award-info":[{"award-number":["31370379"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cellular Molecular Medi"],"published-print":{"date-parts":[[2018,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>Stauntonia chinensis <\/jats:italic><jats:styled-content style=\"fixed-case\">DC<\/jats:styled-content>. has been utilised as a traditional herbal medicine for its anti\u2010hyperglycemic characteristic, which has been associated with triterpene saponins. The goal of the current evaluation was to examine hypoglycemic activity and affiliated mechanism of total saponins from <jats:italic>S.\u00a0chinensis<\/jats:italic>. The chemical composition was analysed by <jats:styled-content style=\"fixed-case\">HPLC<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">ESI<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">MS<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">MS<\/jats:styled-content>. The fasting blood glucose, oral glucose tolerance test, insulin tolerance test, insulin and glycogen levels of type 2 diabetic <jats:italic>db\/db<\/jats:italic> mice administered total saponins were quantified to determine the hypoglycemic effects. The serum lipid profiles were assessed to determine the hypolipidemic effects. Western blotting was used to quantify the protein levels of insulin receptor substrates (<jats:styled-content style=\"fixed-case\">IRS<\/jats:styled-content>)\u20101\/<jats:styled-content style=\"fixed-case\">PI<\/jats:styled-content>3K\/<jats:styled-content style=\"fixed-case\">AKT<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> AMPK<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">ACC<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">GLUT<\/jats:styled-content>4. Twenty triterpene saponins were identified from the total saponins, which exhibited hypoglycemic activities and modulated hyperlipidemia that was associated with type 2 diabetes. The hypoglycemic effects were partly due to the activation of <jats:styled-content style=\"fixed-case\">GLUT<\/jats:styled-content>4, which is regulated by <jats:styled-content style=\"fixed-case\">IRS<\/jats:styled-content>\u20101\/<jats:styled-content style=\"fixed-case\">PI<\/jats:styled-content>3K\/<jats:styled-content style=\"fixed-case\">AKT<\/jats:styled-content>. The activation of the <jats:styled-content style=\"fixed-case\">AMPK<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">ACC<\/jats:styled-content> signalling pathway may be responsible for the hypolipidemic activity. This study revealed that total saponins from <jats:italic>S.\u00a0chinensis<\/jats:italic> have significant hypoglycemic and hypolipidemic activity in diabetic <jats:italic>db\/db<\/jats:italic> mice, indicating that these may be utilised in the development of saponins based on <jats:italic>S.\u00a0chinensis<\/jats:italic> for the treatment of type 2 diabetes.<\/jats:p>","DOI":"10.1111\/jcmm.13876","type":"journal-article","created":{"date-parts":[[2018,10,16]],"date-time":"2018-10-16T08:02:36Z","timestamp":1539676956000},"page":"6026-6038","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":63,"title":["Hypoglycemic and hypolipidemic effects of total saponins from <i>Stauntonia chinensis<\/i> in diabetic <i>db\/db<\/i> mice"],"prefix":"10.1111","volume":"22","author":[{"given":"Jing","family":"Xu","sequence":"first","affiliation":[{"name":"School of Pharmaceutical Sciences South\u2010Central University for Nationalities Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sha","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences South\u2010Central University for Nationalities Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianhui","family":"Feng","sequence":"additional","affiliation":[{"name":"College of Chemistry and Material Sciences South\u2010Central University for Nationalities Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Chen","sequence":"additional","affiliation":[{"name":"College of Chemistry and Material Sciences South\u2010Central University for Nationalities Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9853-5078","authenticated-orcid":false,"given":"Guangzhong","family":"Yang","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences South\u2010Central University for Nationalities Wuhan China"},{"name":"National Demonstration Center for Experimental Ethnopharmacology Education South\u2010Central University for Nationalities Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,10,16]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2006.04.004"},{"key":"e_1_2_7_3_1","volume-title":"IDF Diabetes Atlas","author":"International Diabetes Federation","year":"2017"},{"key":"e_1_2_7_4_1","unstructured":"World Health Organization.The Global Burden of Chronic Diseases 2016.http:\/\/www.who.int\/nutrition\/topics\/2background\/en\/. 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