{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T13:42:21Z","timestamp":1740145341811,"version":"3.37.3"},"reference-count":18,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2018,9,6]],"date-time":"2018-09-06T00:00:00Z","timestamp":1536192000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100009633","name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","doi-asserted-by":"publisher","award":["HD053028"],"award-info":[{"award-number":["HD053028"]}],"id":[{"id":"10.13039\/100009633","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000865","name":"Bill and Melinda Gates Foundation","doi-asserted-by":"publisher","award":["R6 Ph 1"],"award-info":[{"award-number":["R6 Ph 1"]}],"id":[{"id":"10.13039\/100000865","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["U54GM 104944"],"award-info":[{"award-number":["U54GM 104944"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cellular Molecular Medi"],"published-print":{"date-parts":[[2018,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Preterm birth before 37 weeks of completed gestation results in numerous health consequences for the foetus. Preterm labour leads to preterm birth in over 50% of cases, and no FDA\u2010approved treatment can prevent labour or help a foetus remain in the womb until term. Examination of nitric oxide mediated relaxation signaling in the uterine smooth muscle reveals a role for protein S\u2010nitrosation. The recent discovery of upregulated S\u2010nitrosoglutathione reductase (GSNOR) in spontaneously preterm labouring women has emphasized the need to explore the function of S\u2010nitrosation regulation in the maintenance of uterine quiescence. Here we have examined the ability of nebivolol to relax uterine smooth muscle and tested recent claims that nebivolol is a GSNOR inhibitor. In uterine smooth muscle strips from both mouse and human, nebivolol relaxes oxytocin\u2010induced contractions in a dose dependent manner. Our data indicates that nebivolol has no effect on GSNOR activity, nor does nebivolol inhibit thioredoxin reductase, two of the major protein denitrosylases. The ability of nebivolol to relax uterine smooth muscle is likely the combined effects of increased nitric oxide synthase activity and \u03b23\u2010adregnegic stimulation.<\/jats:p>","DOI":"10.1111\/jcmm.13883","type":"journal-article","created":{"date-parts":[[2018,9,6]],"date-time":"2018-09-06T13:17:14Z","timestamp":1536239834000},"page":"6391-6395","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Hiding in Plain Sight: Nebivolol Exhibits Compelling Tocolytic Properties"],"prefix":"10.1111","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2269-2525","authenticated-orcid":false,"given":"Scott D.","family":"Barnett","sequence":"first","affiliation":[{"name":"Pharmacology University of Nevada Reno School of Medicine Reno Nevada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2775-6137","authenticated-orcid":false,"given":"Iain L. O.","family":"Buxton","sequence":"additional","affiliation":[{"name":"Pharmacology University of Nevada Reno School of Medicine Reno Nevada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,9,6]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"1","article-title":"Deaths: preliminary data for 2006","volume":"54","author":"Mini\u00f1o AM","year":"2006","journal-title":"Natl. Vital Stat. Reports"},{"key":"e_1_2_6_3_1","first-page":"1","article-title":"Births: final data for 2011","volume":"62","author":"Martin JA","year":"2013","journal-title":"Natl. Vital Stat. 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