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By using Bmi\u20101<jats:styled-content style=\"fixed-case\"><jats:sup>GFP<\/jats:sup><\/jats:styled-content><jats:sup>\/+<\/jats:sup> mice, we investigated the role of Bmi\u20101 in cardiac stem\/progenitor cells and myocardial repair. <jats:styled-content style=\"fixed-case\">RT<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">PCR<\/jats:styled-content> and flow cytometry analysis indicated that the expression of Bmi\u20101 was significantly higher in cardiac side population than the main population from <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>45<jats:sup>\u2212<\/jats:sup>Ter119<jats:sup>\u2212<\/jats:sup><jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>31<jats:sup>\u2212<\/jats:sup> heart cells. More Sca\u20101<jats:sup>+<\/jats:sup> cardiac stem\/progenitor cells were found in Bmi\u20101 <jats:styled-content style=\"fixed-case\">GFP<\/jats:styled-content><jats:sup>hi<\/jats:sup> subpopulation, and these Bmi\u20101 <jats:styled-content style=\"fixed-case\">GFP<\/jats:styled-content><jats:sup>hi<\/jats:sup> heart cells showed the potential of differentiation into <jats:styled-content style=\"fixed-case\">SMM<\/jats:styled-content><jats:sup>+<\/jats:sup> smooth muscle\u2010like cells and TnT<jats:sup>+<\/jats:sup> cardiomyocyte\u2010like cells in\u00a0vitro. The silencing of Bmi\u20101 significantly inhibited the proliferation and differentiation of heart cells. Otherwise, myocardial infarction induced a significantly increase (2.7\u2010folds) of Bmi\u20101 <jats:styled-content style=\"fixed-case\">GFP<\/jats:styled-content><jats:sup>hi<\/jats:sup> population, mainly within the infarction and border zones. These preliminary data suggest that Bmi\u20101<jats:sup>hi<\/jats:sup> heart cells are enriched in cardiac stem\/progenitor cells and may play a role in myocardial repair.<\/jats:p>","DOI":"10.1111\/jcmm.13889","type":"journal-article","created":{"date-parts":[[2018,11,6]],"date-time":"2018-11-06T00:44:14Z","timestamp":1541465054000},"page":"104-111","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Bmi\u20101 high\u2010expressing cells enrich cardiac stem\/progenitor cells and respond to heart injury"],"prefix":"10.1111","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0567-1447","authenticated-orcid":false,"given":"Yuewang","family":"Song","sequence":"first","affiliation":[{"name":"Department of Cardiology Rui Jin Hospital Shanghai Jiao Tong University School of Medicine Shanghai 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