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This pathological process is accelerated by retinal ischaemia\u2010reperfusion (I\/R) injury. This study investigated whether young <jats:styled-content style=\"fixed-case\">BM<\/jats:styled-content> stem cells can regenerate and repair the aged retina after acute I\/R injury. Young <jats:styled-content style=\"fixed-case\">BM<\/jats:styled-content> stem cell antigen 1 positive (Sca\u20101<jats:sup>+<\/jats:sup>) or Sca\u20101<jats:sup>\u2212<\/jats:sup> cells were transplanted into lethally irradiated aged recipient mice to generate Sca\u20101<jats:sup>+<\/jats:sup> and Sca\u20101<jats:sup>\u2212<\/jats:sup> chimaeras, respectively. The animals were housed for 3 months to allow the young Sca\u20101 cells to repopulate in the <jats:styled-content style=\"fixed-case\">BM<\/jats:styled-content> of aged mice. Retinal I\/R was then induced by elevation of intraocular pressure. Better preservation of visual function was found in Sca\u20101<jats:sup>+<\/jats:sup> than Sca\u20101<jats:sup>\u2212<\/jats:sup> chimaeras 7 days after injury. More Sca\u20101<jats:sup>+<\/jats:sup> cells homed to the retina than Sca\u20101<jats:sup>\u2212<\/jats:sup> cells and more cells differentiated into glial and microglial cells in the Sca\u20101<jats:sup>+<\/jats:sup> chimaeras. After injury, Sca\u20101<jats:sup>+<\/jats:sup> cells in the retina reduced host cellular apoptosis, which was associated with higher expression of fibroblast growth factor 2 (<jats:styled-content style=\"fixed-case\">FGF<\/jats:styled-content>2) in the Sca\u20101<jats:sup>+<\/jats:sup> chimaeras. Young Sca\u20101<jats:sup>+<\/jats:sup> cells repopulated the stem cells in the aged retina and diminished cellular apoptosis after acute I\/R injury through <jats:styled-content style=\"fixed-case\">FGF<\/jats:styled-content>2 and Akt signalling pathways.<\/jats:p>","DOI":"10.1111\/jcmm.13905","type":"journal-article","created":{"date-parts":[[2018,9,26]],"date-time":"2018-09-26T06:15:22Z","timestamp":1537942522000},"page":"6176-6189","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Young bone marrow Sca\u20101 cells protect aged retina from ischaemia\u2010reperfusion injury through activation of <scp>FGF<\/scp>2"],"prefix":"10.1111","volume":"22","author":[{"given":"Zhengbo","family":"Shao","sequence":"first","affiliation":[{"name":"Department of Ophthalmology The Second Affiliated Hospital of Harbin Medical University Harbin China"},{"name":"Research Institute Second Affiliated Hospital of Harbin Medical 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