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However, their role in the radiation\u2010induced intestinal injury is unknown. The goal of the present study was to analyse the potential mechanistic role of lncRNA<\/jats:styled-content>s in the radiation\u2010induced intestinal injury. Mice were divided into two groups: Control (non\u2010irradiated) and irradiated. Irradiated mice were administered 14\u00a0Gy of abdominal irradiation (ABI<\/jats:styled-content>) and were assessed 3.5\u00a0days after irradiation. Changes to the jejuna of ABI<\/jats:styled-content> mice were analysed using RNA<\/jats:styled-content>\u2010Seq for alterations to both lncRNA<\/jats:styled-content> and mRNA<\/jats:styled-content>. These results were validated using qRT<\/jats:styled-content>\u2010PCR<\/jats:styled-content>. LncRNA<\/jats:styled-content>s targets were predicted based on analysis of lncRNA<\/jats:styled-content>s\u2010miRNA<\/jats:styled-content>s\u2010mRNA<\/jats:styled-content>s interaction. 29\u00a0007 lncRNA<\/jats:styled-content>s and 17\u00a0142 mRNA<\/jats:styled-content>s were detected in the two groups. At 3.5\u00a0days post\u2010irradiation, 91 lncRNA<\/jats:styled-content>s and 57 lncRNA<\/jats:styled-content>s were significantly up\u2010 and downregulated respectively. Similarly, 752 mRNA<\/jats:styled-content>s and 400 mRNA<\/jats:styled-content>s were significantly up\u2010 and downregulated respectively. qRT<\/jats:styled-content>\u2010PCR<\/jats:styled-content> was used to verify the altered expression of four lncRNA<\/jats:styled-content>s (ENSMUST<\/jats:styled-content>00000173070, AK<\/jats:styled-content>157361, AK<\/jats:styled-content>083183, AK<\/jats:styled-content>038898) and four mRNA<\/jats:styled-content>s (Mboat1, Nek10, Ccl24, Cyp2c55). Gene ontology and KEGG<\/jats:styled-content> pathway analyses indicated the predicted genes were mainly involved in the VEGF<\/jats:styled-content> signalling pathway. This study reveals that the expression of lncRNA<\/jats:styled-content>s was altered in the jejuna of mice post\u2010irradiation. Moreover, it provides a resource for the study of lncRNA<\/jats:styled-content>s in the radiation\u2010induced intestinal injury.<\/jats:p>","DOI":"10.1111\/jcmm.13940","type":"journal-article","created":{"date-parts":[[2018,10,16]],"date-time":"2018-10-16T08:02:51Z","timestamp":1539676971000},"page":"6357-6367","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Analysis of changes to lncRNAs and their target mRNAs in murine jejunum after radiation treatment"],"prefix":"10.1111","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0810-4483","authenticated-orcid":false,"given":"Qianying","family":"Lu","sequence":"first","affiliation":[{"name":"Institute of Radiation Medicine Chinese Academy of Medical Sciences & Peking Union Medical College Tianjin Key Laboratory of Molecular Nuclear Medicine Tianjin 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