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A subset of male offspring was placed on a high\u2010fat diet (<jats:styled-content style=\"fixed-case\">HF<\/jats:styled-content>, 45% fat) from 4\u201016\u00a0weeks of age. Prenatal hypoxia induced a decrease in birth weight. In offspring\u2010fed <jats:styled-content style=\"fixed-case\">HF<\/jats:styled-content> diet, prenatal hypoxia was associated with increased fasting plasma triglyceride, total cholesterol, free fatty acids, and low\u2010density lipoprotein\u2010cholesterol. Compared with the other three groups, prenatal hypoxic offspring with high\u2010fat diet showed a significant increase in blood pressure, phenylephrine\u2010mediated vasoconstrictions, L\u2010type voltage\u2010gated Ca2+ (Cav1.2) channel currents, and elevated <jats:styled-content style=\"fixed-case\">mRNA<\/jats:styled-content> and protein expression of Cav1.2 \u03b11 subunit in mesenteric arteries or myocytes. The large\u2010conductance Ca2+\u2010activated K+ (<jats:styled-content style=\"fixed-case\">BK<\/jats:styled-content>) channels currents and the <jats:styled-content style=\"fixed-case\">BK<\/jats:styled-content> channel units (\u03b21, not \u03b1\u2010subunits) were significantly increased in mesenteric arteries or myocytes in <jats:styled-content style=\"fixed-case\">HF<\/jats:styled-content> offspring independent of prenatal hypoxia factor.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The results demonstrated that prenatal hypoxia followed by postnatal <jats:styled-content style=\"fixed-case\">HF<\/jats:styled-content> caused vascular dysfunction through ion channel remodelling in myocytes.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jcmm.14020","type":"journal-article","created":{"date-parts":[[2018,12,17]],"date-time":"2018-12-17T01:55:15Z","timestamp":1545011715000},"page":"1183-1196","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Prenatal hypoxia plus postnatal high\u2010fat diet exacerbated vascular dysfunction via up\u2010regulated vascular Cav1.2 channels in offspring rats"],"prefix":"10.1111","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8519-7428","authenticated-orcid":false,"given":"Xiang","family":"Li","sequence":"first","affiliation":[{"name":"Institute for Fetology First Hospital of Soochow University Suzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xueqin","family":"Feng","sequence":"additional","affiliation":[{"name":"Institute for Fetology First Hospital of Soochow University Suzhou 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