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Growing evidence has pointed to a significant role of <jats:styled-content style=\"fixed-case\">SUMO<\/jats:styled-content> in kidney diseases such as <jats:styled-content style=\"fixed-case\">DN<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> RCC<\/jats:styled-content>, nephritis, <jats:styled-content style=\"fixed-case\">AKI<\/jats:styled-content>, hypertonic stress and nephrolithiasis. Recently, emerging studies in podocytes demonstrated that <jats:styled-content style=\"fixed-case\">SUMO<\/jats:styled-content> might have a protective role against podocyte apoptosis. However, the <jats:styled-content style=\"fixed-case\">SUMO<\/jats:styled-content> code responsible for beneficial outcome in the kidney remains to be decrypted. Our recent experiments have revealed that the expression of both <jats:styled-content style=\"fixed-case\">SUMO<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">SUMO<\/jats:styled-content>ylated proteins is appreciably elevated in hypoxia\u2010induced tubular epithelial cells (<jats:styled-content style=\"fixed-case\">TEC<\/jats:styled-content>s) as well as in the unilateral ureteric obstruction (<jats:styled-content style=\"fixed-case\">UUO<\/jats:styled-content>) mouse model, suggesting a role of <jats:styled-content style=\"fixed-case\">SUMO<\/jats:styled-content> in <jats:styled-content style=\"fixed-case\">TEC<\/jats:styled-content>s injury and renal fibrosis. In this review, we attempt to decipher the <jats:styled-content style=\"fixed-case\">SUMO<\/jats:styled-content> code in the development of kidney diseases by summarizing the defined function of <jats:styled-content style=\"fixed-case\">SUMO<\/jats:styled-content> and looking forward to the potential role of <jats:styled-content style=\"fixed-case\">SUMO<\/jats:styled-content> in kidney diseases, especially in the pathology of renal fibrosis and <jats:styled-content style=\"fixed-case\">CKD<\/jats:styled-content>, with the goal of developing strategies that maximize correct interpretation in clinical therapy and prognosis.<\/jats:p>","DOI":"10.1111\/jcmm.14021","type":"journal-article","created":{"date-parts":[[2018,12,2]],"date-time":"2018-12-02T05:10:02Z","timestamp":1543727402000},"page":"711-719","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Deciphering the <scp>SUMO<\/scp> code in the 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