{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T11:28:34Z","timestamp":1773833314264,"version":"3.50.1"},"reference-count":49,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2019,1,28]],"date-time":"2019-01-28T00:00:00Z","timestamp":1548633600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81570622"],"award-info":[{"award-number":["81570622"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81570658"],"award-info":[{"award-number":["81570658"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cellular Molecular Medi"],"published-print":{"date-parts":[[2019,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Long\u2010term peritoneal dialysis (<jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content>) can lead to the induction of mesothelial\/epithelial\u2010mesenchymal transition (<jats:styled-content style=\"fixed-case\">MMT<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">EMT<\/jats:styled-content>) and fibrosis; these effects eventually result in ultrafiltration failure and the discontinuation of <jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content>. Micro<jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content>\u2010302c (miR\u2010302c) is believed to be involved in regulating tumour cell growth and metastasis by suppressing <jats:styled-content style=\"fixed-case\">MMT<\/jats:styled-content>, but the effect of miR\u2010302c on <jats:styled-content style=\"fixed-case\">MMT<\/jats:styled-content> in the context of <jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content> is unknown. MiR\u2010302c levels were measured in mesothelial cells isolated from the <jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content> effluents of continuous ambulatory peritoneal dialysis patients. After miR\u2010302c overexpression using lentivirus, human peritoneal mesothelial cell line (<jats:styled-content style=\"fixed-case\">HM<\/jats:styled-content>r<jats:styled-content style=\"fixed-case\">SV<\/jats:styled-content>5) and <jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content> mouse peritoneum were treated with <jats:styled-content style=\"fixed-case\">TGF<\/jats:styled-content>\u2010\u03b21 or high glucose peritoneal dialysate respectively. MiR\u2010302c expression level and <jats:styled-content style=\"fixed-case\">MMT<\/jats:styled-content>\u2010related factors alteration were observed. In addition, fibrosis of <jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content> mouse peritoneum was alleviated by miR\u2010302c overexpression. Furthermore, the expression of connective tissue growth factor (<jats:styled-content style=\"fixed-case\">CTGF<\/jats:styled-content>) was negatively related by miR\u2010302c, and <jats:styled-content style=\"fixed-case\">LV<\/jats:styled-content>\u2010miR\u2010302c reversed the up\u2010regulation of <jats:styled-content style=\"fixed-case\">CTGF<\/jats:styled-content> induced by <jats:styled-content style=\"fixed-case\">TGF<\/jats:styled-content>\u2010\u03b21. These data suggest that there is a novel <jats:styled-content style=\"fixed-case\">TGF<\/jats:styled-content>\u2010\u03b21\/miR\u2010302c\/<jats:styled-content style=\"fixed-case\">CTGF<\/jats:styled-content> pathway that plays a significant role in the process of <jats:styled-content style=\"fixed-case\">MMT<\/jats:styled-content> and fibrosis during <jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content>. MiR\u2010302c might be a potential biomarker for peritoneal fibrosis and a novel therapeutic target for protection against peritoneal fibrosis in <jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content> patients.<\/jats:p>","DOI":"10.1111\/jcmm.14029","type":"journal-article","created":{"date-parts":[[2019,1,29]],"date-time":"2019-01-29T06:56:25Z","timestamp":1548744985000},"page":"2372-2383","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["MicroRNA\u2010302c modulates peritoneal dialysis\u2010associated fibrosis by targeting connective tissue growth factor"],"prefix":"10.1111","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8163-814X","authenticated-orcid":false,"given":"Xiejia","family":"Li","sequence":"first","affiliation":[{"name":"Department of Nephrology The Second Xiangya Hospital Central South University Changsha China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Nephrology The Second Xiangya Hospital Central South University Changsha China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lin","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Nephrology The Second Xiangya Hospital Central South University Changsha China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xun","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Nephrology The Second Xiangya Hospital Central South University Changsha China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinke","family":"Yuan","sequence":"additional","affiliation":[{"name":"Department of Nephrology The Second Xiangya Hospital Central South University Changsha China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yusa","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Nephrology The Second Xiangya Hospital Central South University Changsha China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fuyou","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Nephrology The Second Xiangya Hospital Central South University Changsha China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Nephrology The Second Xiangya Hospital Central South University Changsha China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Xiao","sequence":"additional","affiliation":[{"name":"Department of Nephrology The Second Xiangya Hospital Central South University Changsha China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,1,28]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.V132470"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2009070694"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.3747\/pdi.2014.00188"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2015.00113"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.15252\/emmm.201404127"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.2478\/s11658-014-0199-z"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trsl.2015.10.009"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/labinvest.2015.57"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2004.02.019"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1534-5807(03)00227-2"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/emboj.2010.319"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2009.241"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10549-011-1672-2"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0023584"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2011.0081"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0021253"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/scrp05524"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1159\/000232937"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.12-219378"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00368.2009"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.3109\/0886022X.2013.844645"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.4103\/1319-2442.135004"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12860-015-0055-7"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/263285"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2013.05.019"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfs049"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2008020211"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0094639"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1158\/1535-7163.MCT-13-0448"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11010-013-1950-x"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10549-013-2753-1"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0611192104"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2016.09.154"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/673096"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1038\/labinvest.2014.91"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2013.01.031"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1159\/000362622"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.3747\/pdi.2014.00125"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.V133721"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12935-014-0072-1"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molimm.2014.12.017"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.2174\/15680096113136660102"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0053238"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.2174\/1566524014666140331230411"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00094.2012"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.1159\/000322255"},{"key":"e_1_2_7_48_1","doi-asserted-by":"publisher","DOI":"10.3109\/0886022X.2011.559681"},{"key":"e_1_2_7_49_1","first-page":"907","article-title":"Influence of glucose and inflammatory cytokines on TGF\u2010beta1 and CTGF mRNA expression in human peritoneal mesothelial cells","volume":"15","author":"Sakamato N","year":"2005","journal-title":"Int J Mol Med"},{"key":"e_1_2_7_50_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.105528"}],"container-title":["Journal of Cellular and Molecular Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjcmm.14029","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jcmm.14029","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jcmm.14029","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jcmm.14029","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,22]],"date-time":"2023-08-22T05:27:13Z","timestamp":1692682033000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jcmm.14029"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1,28]]},"references-count":49,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2019,4]]}},"alternative-id":["10.1111\/jcmm.14029"],"URL":"https:\/\/doi.org\/10.1111\/jcmm.14029","archive":["Portico"],"relation":{},"ISSN":["1582-1838","1582-4934"],"issn-type":[{"value":"1582-1838","type":"print"},{"value":"1582-4934","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,1,28]]},"assertion":[{"value":"2018-05-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-10-22","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-01-28","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}