{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T20:42:32Z","timestamp":1788381752613,"version":"build-2803163510"},"reference-count":29,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2019,2,7]],"date-time":"2019-02-07T00:00:00Z","timestamp":1549497600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cellular Molecular Medi"],"published-print":{"date-parts":[[2019,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Endometriosis is a chronic inflammatory syndrome and nearly 6%\u201010% of women are affected by it during the reproductive period. Previous studies have proved that microRNAs (miRNAs) are implicated in the pathogenesis of ovarian endometriosis. In this study, we aimed to investigate that restored miR\u2010488 would effectively inhibit the development of endometriosis. The microarray\u2010based data analysis was performed to screen endometriosis\u2010related differentially expressed genes (DEGs). The mouse model in endometriosis syndrome was established by being subcutaneously injected with Estradiol benzoate, and the ectopic endometrial tissues and normal endometrial tissues were collected. Additionally, the endometrial glandular epithelial cells were extracted from the endometrial glandular epithelial tissues from normal and endometriosis mice. In order to examine the role of miR\u2010488 in mice with endometriosis, we measured miR\u2010488 expression and expression levels of Frizzled\u20107 (FZD7), cyclinD1, \u03b2\u2010catenin, and c\u2010Myc in vivo and in vitro. Finally, we detected the effect of miR\u2010488 on cell proliferation, apoptosis, migration and invasion in vitro. FZD7 was upregulated in human endometriosis. The data showed higher expression levels of FZD7, \u03b2\u2010catenin, c\u2010Myc and cyclinD1, and lower miR\u2010488 expression in mouse endometrial tissues. FZD7 was the target gene of miR\u2010488. Furthermore, elevated miR\u2010488 in isolated mouse endometrial glandular endometrial cells inhibited FZD7, the translocation of \u03b2\u2010catenin to nucleus, the activation of Wnt pathway, and the cell proliferation, migration and invasion. Collectively, these findings indicated that up\u2010regulated miR\u2010488 may reduce the proliferation, migration and invasion of endometrial glandular epithelial cells through inhibiting the activation of Wnt pathway by down\u2010regulating FZD7.<\/jats:p>","DOI":"10.1111\/jcmm.14078","type":"journal-article","created":{"date-parts":[[2019,2,7]],"date-time":"2019-02-07T09:37:43Z","timestamp":1549532263000},"page":"2419-2430","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["MicroRNA\u2010488 inhibits endometrial glandular epithelial cell proliferation, migration, and invasion in endometriosis mice via Wnt by inhibiting FZD7"],"prefix":"10.1111","volume":"23","author":[{"given":"Hui","family":"Zhu","sequence":"first","affiliation":[{"name":"Department of Reproductive Health Nanjing Maternity and Child Health Care Hospital, The Affiliated Obstetrics and Gynecology Hospital of Nanjing Medical University Nanjing P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xi\u2010Xia","family":"Cao","sequence":"additional","affiliation":[{"name":"Department of Reproductive Health Nanjing Maternity and Child Health Care Hospital, The Affiliated Obstetrics and Gynecology Hospital of Nanjing Medical University Nanjing P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Gynecology Nanjing Maternity and Child Health Care Hospital, The Affiliated Obstetrics and Gynecology Hospital of Nanjing Medical University Nanjing P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1770-0551","authenticated-orcid":false,"given":"Hua","family":"Hua","sequence":"additional","affiliation":[{"name":"Department of Reproductive Health Nanjing Maternity and Child Health Care Hospital, The Affiliated Obstetrics and Gynecology Hospital of Nanjing Medical University Nanjing P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,2,7]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"349","article-title":"Endometriosis still a challenge","volume":"7","author":"Mehedintu C","year":"2014","journal-title":"J Med Life"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/236821"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrendo.2013.255"},{"key":"e_1_2_7_5_1","first-page":"107","article-title":"Evaluation and treatment of endometriosis","volume":"87","author":"Schrager S","year":"2013","journal-title":"Am Fam Physician"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/1477-7827-12-50"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1517\/14728214.2015.1051966"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.2174\/18722156113079990021"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2015.02.030"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/deu019"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.20941"},{"key":"e_1_2_7_12_1","first-page":"2070","article-title":"MiR\u2010488 suppresses cell proliferation and invasion by targeting ADAM9 and lncRNA HULC in hepatocellular carcinoma","volume":"7","author":"Hu D","year":"2017","journal-title":"Am J Cancer Res"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.10465"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.13292"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2005-0790"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/16.8.1736"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1369\/jhc.3A6195.2004"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1159\/000475941"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.19586"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2017.06.185"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.6742"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1210\/me.2010-0371"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1093\/biolre\/ioy019"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2017.7130"},{"key":"e_1_2_7_25_1","first-page":"1051","article-title":"Comparative genomics on Fzd7 orthologs","volume":"15","author":"Katoh M","year":"2005","journal-title":"Int J Mol Med"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellsig.2011.12.009"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1186\/1423-0127-20-31"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13277-015-4645-y"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.116.307926"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2014.02.040"}],"container-title":["Journal of Cellular and Molecular Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jcmm.14078","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jcmm.14078","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jcmm.14078","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,22]],"date-time":"2023-08-22T05:27:41Z","timestamp":1692682061000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jcmm.14078"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,2,7]]},"references-count":29,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2019,4]]}},"alternative-id":["10.1111\/jcmm.14078"],"URL":"https:\/\/doi.org\/10.1111\/jcmm.14078","archive":["Portico"],"relation":{},"ISSN":["1582-1838","1582-4934"],"issn-type":[{"value":"1582-1838","type":"print"},{"value":"1582-4934","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,2,7]]},"assertion":[{"value":"2018-07-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-11-13","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-02-07","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}