{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T06:14:45Z","timestamp":1791267285274,"version":"4.1.0"},"reference-count":36,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2019,1,4]],"date-time":"2019-01-04T00:00:00Z","timestamp":1546560000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"The Key Laboratory Program of Liaoning Provincial Department of Education Ministration","award":["LZ2015051"],"award-info":[{"award-number":["LZ2015051"]}]},{"DOI":"10.13039\/501100001809","name":"The National Natural Foundation of China","doi-asserted-by":"crossref","award":["81470388"],"award-info":[{"award-number":["81470388"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cellular Molecular Medi"],"published-print":{"date-parts":[[2019,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>In addition to the known antitumour effects of ursolic acid (UA), increasing evidence indicates that this molecule plays a role in cardiac protection. In this study, the effects of ursolic acid on the heart in mice treated with doxorubicin (DOX) were assessed. The results showed that ursolic acid improved left ventrical fractional shortening (LVFS) and left ventrical ejection fraction (LVEF) of the heart, increased nitrogen oxide (NO) levels, inhibited reactive oxygen species (ROS) production and decreased cardiac apoptosis in mice treated with doxorubicin. Mechanistically, ursolic acid increased AKT and endothelial nitric\u2010oxide synthase (eNOS) phosphorylation levels, and enhanced eNOS expression, while inhibiting doxorubicin induced eNOS uncoupling through NADPH oxidase 4 (NOX4) down\u2010regulation. These effects of ursolic acid resulted in heart protection from doxorubicin\u2010induced injury. Therefore, ursolic acid may be considered a potential therapeutic agent for doxorubicin\u2010associated cardiac toxicity in clinical practice.<\/jats:p>","DOI":"10.1111\/jcmm.14130","type":"journal-article","created":{"date-parts":[[2019,1,4]],"date-time":"2019-01-04T14:10:52Z","timestamp":1546611052000},"page":"2174-2183","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":43,"title":["Ursolic acid prevents doxorubicin\u2010induced cardiac toxicity in mice through eNOS activation and inhibition of eNOS uncoupling"],"prefix":"10.1111","volume":"23","author":[{"given":"Haiman","family":"Mu","sequence":"first","affiliation":[{"name":"First Affiliated Hospital of Jinzhou Medical University Jinzhou China"},{"name":"Graduated School of Jinzhou Medical University Jinzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haiwen","family":"Liu","sequence":"additional","affiliation":[{"name":"First Affiliated Hospital 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