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Our previous data have shown that <jats:styled-content style=\"fixed-case\">MAFF<\/jats:styled-content>, a member of the <jats:styled-content style=\"fixed-case\">MAF<\/jats:styled-content> family of <jats:styled-content style=\"fixed-case\">bZIP<\/jats:styled-content> transcription factors, is rapidly induced by pro\u2010inflammatory cytokines in <jats:styled-content style=\"fixed-case\">PHM<\/jats:styled-content>1\u201031 myometrial cells. We performed loss\u2010of\u2010function studies in <jats:styled-content style=\"fixed-case\">PHM<\/jats:styled-content>1\u201031 cells to identify <jats:styled-content style=\"fixed-case\">MAFF<\/jats:styled-content> dependent genes. We showed that knockdown of <jats:styled-content style=\"fixed-case\">MAFF<\/jats:styled-content> significantly decreased <jats:styled-content style=\"fixed-case\">CXCL<\/jats:styled-content>1 chemokine and <jats:styled-content style=\"fixed-case\">CSF<\/jats:styled-content>3 cytokine transcript and protein levels. Using chromatin immunoprecipitation analyzes, we confirmed <jats:italic><jats:styled-content style=\"fixed-case\">CXCL<\/jats:styled-content>1<\/jats:italic> and <jats:italic><jats:styled-content style=\"fixed-case\">CSF<\/jats:styled-content>3<\/jats:italic> genes as direct <jats:styled-content style=\"fixed-case\">MAFF<\/jats:styled-content> targets. We also demonstrated that <jats:styled-content style=\"fixed-case\">MAFF<\/jats:styled-content> function in <jats:styled-content style=\"fixed-case\">PHM<\/jats:styled-content>1\u201031 myometrial cells is able to control cytokine and matrix metalloproteinase gene expression in <jats:styled-content style=\"fixed-case\">THP<\/jats:styled-content>\u20101 monocytic cells in a paracrine fashion. Our studies provide valuable insights into the <jats:styled-content style=\"fixed-case\">MAFF<\/jats:styled-content> dependent transcriptional network governing myometrial cell function. The data suggest a role of <jats:styled-content style=\"fixed-case\">MAFF<\/jats:styled-content> in parturition and\/or infection\u2010induced preterm labour through modulation of inflammatory processes in the microenvironment.<\/jats:p>","DOI":"10.1111\/jcmm.14136","type":"journal-article","created":{"date-parts":[[2019,1,24]],"date-time":"2019-01-24T05:48:33Z","timestamp":1548308913000},"page":"2517-2525","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Regulation of <scp>CXCL<\/scp>1 chemokine and <scp>CSF<\/scp>3 cytokine levels in myometrial cells by the <scp>MAFF<\/scp> transcription factor"],"prefix":"10.1111","volume":"23","author":[{"given":"James","family":"Saliba","sequence":"first","affiliation":[{"name":"Lady Davis Institute for Medical Research Montreal Quebec 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