{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T04:45:12Z","timestamp":1789965912686,"version":"4.0.1"},"reference-count":15,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2019,2,1]],"date-time":"2019-02-01T00:00:00Z","timestamp":1548979200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["5R01HL051387"],"award-info":[{"award-number":["5R01HL051387"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000968","name":"American Heart Association","doi-asserted-by":"publisher","award":["16GRNT31130010"],"award-info":[{"award-number":["16GRNT31130010"]}],"id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000968","name":"American Heart Association","doi-asserted-by":"publisher","award":["18IPA34170365"],"award-info":[{"award-number":["18IPA34170365"]}],"id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cellular Molecular Medi"],"published-print":{"date-parts":[[2019,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Epigenetic dysregulation plays a crucial role in cardiovascular diseases. Previously, we reported that acetyltransferase p300 (ATp300) inhibitor L002 prevents hypertension\u2010induced cardiac hypertrophy and fibrosis in a murine model. In this short communication, we show that treatment of hypertensive mice with ATp300\u2010specific small molecule inhibitor L002 or C646 reverses hypertension\u2010induced left ventricular hypertrophy, cardiac fibrosis and diastolic dysfunction, without reducing elevated blood pressures. Biochemically, treatment with L002 and C646 also reverse hypertension\u2010induced histone acetylation and myofibroblast differentiation in murine ventricles. Our results confirm and extend the role of ATp300, a major epigenetic regulator, in the pathobiology of cardiac hypertrophy and fibrosis. Most importantly, we identify the efficacies of ATp300 inhibitors C646 and L002 in reversing hypertension\u2010induced cardiac hypertrophy and fibrosis, and discover new anti\u2010hypertrophic and anti\u2010fibrotic candidates.<\/jats:p>","DOI":"10.1111\/jcmm.14162","type":"journal-article","created":{"date-parts":[[2019,2,2]],"date-time":"2019-02-02T02:23:26Z","timestamp":1549074206000},"page":"3026-3031","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":73,"title":["Acetyltransferase p300 inhibitor reverses hypertension\u2010induced cardiac fibrosis"],"prefix":"10.1111","volume":"23","author":[{"given":"Rahul","family":"Rai","sequence":"first","affiliation":[{"name":"Feinberg School of Medicine Feinberg Cardiovascular and Renal Research Institute, Northwestern University  Chicago IL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianjiao","family":"Sun","sequence":"additional","affiliation":[{"name":"Feinberg 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