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Current clinical treatments cannot efficiently or fully prevent the occurrence of post\u2010irradiation dermatitis, which remains a significant clinical problem. Resolving this challenge requires gaining a better understanding of the precise pathophysiology, which in turn requires establishment of a suitable animal model that mimics the clinical condition, and can also be used to investigate the mechanism and explore effective treatment options. In this study, a single dose of 90\u00a0Gy irradiation to rats resulted in ulceration, dermal thickening, inflammation, hair follicle loss, and sebaceous glands loss, indicating successful establishment of the model. Few hair follicle cells migrated to form epidermal cells, and both the severity of skin fibrosis and hydroxyproline levels increased with time post\u2010irradiation. Radiation damaged the mitochondria and induced both apoptosis and autophagy of the skin cells. Therefore, irradiation of 90\u00a0Gy can be used to successfully establish a rat model of radiation\u2010induced dermatitis. This model will be helpful for developing new treatments and gaining a better understanding of the pathological mechanism of radiation\u2010induced dermatitis. Specifically, our results suggest autophagy regulation as a potentially effective therapeutic target.<\/jats:p>","DOI":"10.1111\/jcmm.14174","type":"journal-article","created":{"date-parts":[[2019,3,1]],"date-time":"2019-03-01T01:47:33Z","timestamp":1551404853000},"page":"3178-3189","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["Establishment and characterization of a radiation\u2010induced dermatitis rat model"],"prefix":"10.1111","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0558-6616","authenticated-orcid":false,"given":"Xiaowu","family":"Sheng","sequence":"first","affiliation":[{"name":"Hunan Branch Center, National Tissue Engineering Center of China, Translational Medical Center, Central Laboratory, Hunan Cancer Hospital and The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University Changsha Hunan Province 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