{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T18:52:17Z","timestamp":1776365537017,"version":"3.51.2"},"reference-count":40,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2019,2,7]],"date-time":"2019-02-07T00:00:00Z","timestamp":1549497600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cellular Molecular Medi"],"published-print":{"date-parts":[[2019,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>As a major class of regulatory genes in majority metazoans, microRNAs (miRs) play an important role in various diseases including diabetes mellitus (DM). Lack of androgens has previously been associated with DM\u2010induced erectile dysfunction (DMED). In addition, the biological functioning of androgen is mediated by androgen receptor (AR). Herein, we sought to investigate whether miRs participate in AR\u2010associated DMED. Sprague\u2010Dawlay rats were employed to establish DMED models. After modelling, levels of miR\u2010205 and AR in their cavernous bodies were measured. The relationship between miR\u2010205 and AR was verified using a dual\u2010luciferase reporter gene assay. The underlying regulatory mechanisms of miR\u2010205 were investigated in concert with the treatment of mimics or inhibitors of miR\u2010205, or AR overexpression in the cavernous smooth muscle cells (CSMCs) isolated from rats with DMED. Meanwhile, the effects of miR\u2010205 and AR on cell proliferation and apoptosis were evaluated using MTT assay and flow cytometry respectively. Rats with DMED presented with increased miR\u2010205 and decreased AR levels in the cavernous bodies. AR was identified as a target gene of miR\u2010205. Down\u2010regulation of miR\u2010205 or up\u2010regulation of AR could increase proliferation and inhibits apoptosis of CSMCs in addition to improvements in the erectile functioning of rats with DMED. In summary, miR\u2010205 may contribute to the pathogenesis of DMED via down\u2010regulation of AR expressions.<\/jats:p>","DOI":"10.1111\/jcmm.14212","type":"journal-article","created":{"date-parts":[[2019,2,7]],"date-time":"2019-02-07T09:32:28Z","timestamp":1549531948000},"page":"3257-3270","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["MicroRNA\u2010205 is associated with diabetes mellitus\u2010induced erectile dysfunction via down\u2010regulating the androgen receptor"],"prefix":"10.1111","volume":"23","author":[{"given":"Yan","family":"Wen","sequence":"first","affiliation":[{"name":"Department of Endocrinology China\u2010Japan Union Hospital of Jilin University Changchun China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guohui","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Cardiology China\u2010Japan Union Hospital of Jilin University Changchun 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