{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T14:49:55Z","timestamp":1790520595705,"version":"4.1.0"},"reference-count":48,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2019,4,4]],"date-time":"2019-04-04T00:00:00Z","timestamp":1554336000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cellular Molecular Medi"],"published-print":{"date-parts":[[2019,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The precise mechanisms of SDF\u20101 (CXCL12) in angiogenesis are not fully elucidated. Recently, we showed that Notch inhibition induces extensive intussusceptive angiogenesis by recruitment of mononuclear cells and it was associated with increased levels of SDF\u20101 and CXCR4. In the current study, we demonstrated SDF\u20101 expression in liver sinusoidal vessels of Notch1 knockout mice with regenerative hyperplasia by means of intussusception, but we did not detect any SDF\u20101 expression in wild\u2010type mice with normal liver vessel structure. In addition, pharmacological inhibition of SDF\u20101\/CXCR4 signalling by AMD3100 perturbs intussusceptive vascular growth and abolishes mononuclear cell recruitment in the chicken area vasculosa. In contrast, treatment with recombinant SDF\u20101 protein increased microvascular density by 34% through augmentation of pillar number compared to controls. The number of extravasating mononuclear cells was four times higher after SDF\u20101 application and two times less after blocking this pathway. Bone marrow\u2010derived mononuclear cells (BMDC) were recruited to vessels in response to elevated expression of SDF\u20101 in endothelial cells. They participated in formation and stabilization of pillars. The current study is the first report to implicate SDF\u20101\/CXCR4 signalling in intussusceptive angiogenesis and further highlights the stabilizing role of BMDC in the formation of pillars during vascular remodelling.<\/jats:p>","DOI":"10.1111\/jcmm.14269","type":"journal-article","created":{"date-parts":[[2019,4,5]],"date-time":"2019-04-05T14:00:18Z","timestamp":1554472818000},"page":"3916-3926","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":44,"title":["SDF\u20101\/CXCR4 signalling is involved in blood vessel growth and remodelling by intussusception"],"prefix":"10.1111","volume":"23","author":[{"given":"Ivanka","family":"Dimova","sequence":"first","affiliation":[{"name":"Institute of Anatomy, University of Bern Bern Switzerland"},{"name":"Center of Molecular Medicine Medical University Sofia Sofia 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