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It is expressed during inflammation, in tumour and ischaemic tissue, in the central nervous system and non\u2010neuronal injury environments. Endoplasmic reticulum stress (ERS) is caused by the accumulation of misfolded proteins that interferes with intracellular calcium homoeostasis. Our recent reports showed ASIC1a and ERS are involved in liver fibrosis progression, particularly in hepatic stellate cell (HSC) activation. In this study, we investigated the roles of ASIC1a and ERS in activated HSC. We found that ASIC1a and ERS\u2010related proteins were up\u2010regulated in carbon tetrachloride (CCl<jats:sub>4<\/jats:sub>)\u2010induced fibrotic mouse liver tissues, and in patient liver tissues with hepatocellular carcinoma with severe liver fibrosis. The results show silencing ASIC1a reduced the expression of ERS\u2010related biomarkers GRP78, Caspase12 and IREI\u2010XBP1. And, ERS inhibition by 4\u2010PBA down\u2010regulated the high expression of ASIC1a induced by PDGF, suggesting an interactive relationship. In PDGF\u2010induced HSCs, ASIC1a was activated and migrated to the cell membrane, leading to extracellular calcium influx and ERS, which was mediated by PI3K\/AKT pathway. Our work shows PDGF\u2010activated ASIC1a via the PI3K\/AKT pathway, induced ERS and promoted liver fibrosis progression.<\/jats:p>","DOI":"10.1111\/jcmm.14275","type":"journal-article","created":{"date-parts":[[2019,4,2]],"date-time":"2019-04-02T08:25:49Z","timestamp":1554193549000},"page":"3940-3950","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":47,"title":["PI3\u2010kinase\/Akt pathway\u2010regulated membrane transportation of acid\u2010sensing ion channel 1a\/Calcium ion influx\/endoplasmic reticulum stress activation on PDGF\u2010induced HSC Activation"],"prefix":"10.1111","volume":"23","author":[{"given":"Longquan","family":"Zuo","sequence":"first","affiliation":[{"name":"Department of Pharmacy Hospital of Armed Police of Anhui Province Hefei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yueqin","family":"Zhu","sequence":"additional","affiliation":[{"name":"School of Pharmacy Anhui Medical 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