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Despite its aetiology and potential therapeutics are poorly understood, bioenergetic deficits have been demonstrated in adverse foetal and cardiac development. We aimed to evaluate the role of mitochondria in human pregnancies with IUGR. In a single\u2010site, cross\u2010sectional and observational study, we included placenta and maternal peripheral and neonatal cord blood mononuclear cells (PBMC and CBMC) from 14 IUGR and 22 control pregnancies. The following mitochondrial measurements were assessed: enzymatic activities of mitochondrial respiratory chain (MRC) complexes I, II, IV, I\u00a0+\u00a0III and II\u00a0+\u00a0III, oxygen consumption (cell and complex I\u2010stimulated respiration), mitochondrial content (citrate synthase [CS] activity and mitochondrial DNA copy number), total ATP levels and lipid peroxidation. Sirtuin3 expression was evaluated as a potential regulator of bioenergetic imbalance. Intrauterine growth restriction placental tissue showed a significant decrease of MRC CI enzymatic activity (\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0&lt;\u00a00.05) and CI\u2010stimulated oxygen consumption (\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0&lt;\u00a00.05) accompanied by a significant increase of Sirtuin3\/\u03b2\u2010actin protein levels (\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0&lt;\u00a00.05). Maternal PBMC and neonatal CBMC from IUGR patients presented a not significant decrease in oxygen consumption (cell and CI\u2010stimulated respiration) and MRC enzymatic activities (CII and CIV). Moreover, CS activity was significantly reduced in IUGR new\u2010borns (\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0&lt;\u00a00.05). Total ATP levels and lipid peroxidation were preserved in all the studied tissues. Altered mitochondrial function of IUGR is especially present at placental and neonatal level, conveying potential targets to modulate obstetric outcome through dietary interventions aimed to regulate Sirtuin3 function.\n                  <\/jats:p>","DOI":"10.1111\/jcmm.14282","type":"journal-article","created":{"date-parts":[[2019,4,3]],"date-time":"2019-04-03T00:12:23Z","timestamp":1554250343000},"page":"3962-3973","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Mitochondrial implications in human pregnancies with intrauterine growth restriction and associated cardiac remodelling"],"prefix":"10.1111","volume":"23","author":[{"given":"Mariona","family":"Guitart\u2010Mampel","sequence":"first","affiliation":[{"name":"Muscle Research and Mitochondrial Function Laboratory, Faculty of Medicine and Health Sciences Internal Medicine Service\u2010Hospital Cl\u00ednic of Barcelona, Cellex\u2010IDIBAPS, University of Barcelona Barcelona Spain"},{"name":"CIBERER\u2010U722 Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diana L.","family":"Juarez\u2010Flores","sequence":"additional","affiliation":[{"name":"Muscle Research and Mitochondrial Function Laboratory, Faculty of Medicine and Health Sciences Internal Medicine Service\u2010Hospital Cl\u00ednic of Barcelona, Cellex\u2010IDIBAPS, University of Barcelona Barcelona Spain"},{"name":"CIBERER\u2010U722 Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lina","family":"Youssef","sequence":"additional","affiliation":[{"name":"BCNatal\u2014Barcelona Center for Maternal\u2010Fetal and Neonatal Medicine (Hospital Cl\u00ednic and Hospital Sant Joan de D\u00e9u), IDIBAPS, University of Barcelona Barcelona Spain"},{"name":"CIBERER\u2010U719 Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Constanza","family":"Moren","sequence":"additional","affiliation":[{"name":"Muscle Research and Mitochondrial Function Laboratory, Faculty of Medicine and Health Sciences Internal Medicine Service\u2010Hospital Cl\u00ednic of Barcelona, Cellex\u2010IDIBAPS, University of Barcelona Barcelona Spain"},{"name":"CIBERER\u2010U722 Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Garcia\u2010Otero","sequence":"additional","affiliation":[{"name":"BCNatal\u2014Barcelona Center for Maternal\u2010Fetal and Neonatal Medicine (Hospital Cl\u00ednic and Hospital Sant Joan de D\u00e9u), IDIBAPS, University of Barcelona Barcelona Spain"},{"name":"CIBERER\u2010U719 Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vicente","family":"Roca\u2010Agujetas","sequence":"additional","affiliation":[{"name":"Muscle Research and Mitochondrial Function Laboratory, Faculty of Medicine and Health Sciences Internal Medicine Service\u2010Hospital Cl\u00ednic of Barcelona, Cellex\u2010IDIBAPS, University of Barcelona Barcelona 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