{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T19:38:04Z","timestamp":1791488284607,"version":"4.3.4"},"reference-count":34,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2019,3,25]],"date-time":"2019-03-25T00:00:00Z","timestamp":1553472000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81602677"],"award-info":[{"award-number":["81602677"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81872472"],"award-info":[{"award-number":["81872472"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cellular Molecular Medi"],"published-print":{"date-parts":[[2019,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Radiation enteritis (RE) is the most common complication of radiotherapy for pelvic irradiation receivers. Herein we investigated the alterations in gut microbial profiles and their association with enteritis in patients undergoing pelvic radiotherapy. Faecal samples were collected from 18 cervical cancer patients during radiotherapy. Microbiota profiles were characterized based on 16S rRNA sequencing using the Illumina HiSeq platform. Epithelial inflammatory response was evaluated using bacterial\u2010epithelial co\u2010cultures. Dysbiosis was observed among patients with RE, which was characterized by significantly reduced \u03b1\u2010diversity but increased \u03b2\u2010diversity, relative higher abundance of\n                    <jats:italic>Proteobacteria<\/jats:italic>\n                    and\n                    <jats:italic>Gammaproteobacteria<\/jats:italic>\n                    and lower abundance of\n                    <jats:italic>Bacteroides<\/jats:italic>\n                    <jats:italic>.<\/jats:italic>\n                    <jats:italic>Coprococcus<\/jats:italic>\n                    was clearly enriched prior to radiotherapy in patients who later developed RE. Metastat analysis further revealed unique grade\u2010related microbial features, such as more abundant\n                    <jats:italic>Virgibacillus<\/jats:italic>\n                    and\n                    <jats:italic>Alcanivorax<\/jats:italic>\n                    in patients with mild enteritis. Additionally, using bacterial\u2010epithelial co\u2010cultures, RE patient\u2010derived microbiota induced epithelial inflammation and barrier dysfunction, enhanced TNF\u2010\u03b1 and IL\u20101\u03b2 expression compared with control microbiota. Taken together, we define the overall picture of gut microbiota in patients with RE. Our results suggest that dysbiosis of gut microbiota may contribute to development and progression of RE. Gut microbiota can offer a set of biomarkers for prediction, disease activity evaluation and treatment selection in RE.\n                  <\/jats:p>","DOI":"10.1111\/jcmm.14289","type":"journal-article","created":{"date-parts":[[2019,3,25]],"date-time":"2019-03-25T15:05:25Z","timestamp":1553526325000},"page":"3747-3756","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":178,"title":["Gut microbial dysbiosis is associated with development and progression of radiation enteritis during pelvic radiotherapy"],"prefix":"10.1111","volume":"23","author":[{"given":"Zhongqiu","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer Tianjin's Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingxin","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer Tianjin's Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy Tianjin China"},{"name":"Department of Biomedical Engineering Tianjin University Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xia","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal Oncology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer Tianjin's Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer Tianjin's Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer Tianjin's Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bailin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer Tianjin's Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ye","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Guangdong Provincial Key Laboratory of Gastroenterology Nanfang Hospital, Southern Medical University Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3134-7790","authenticated-orcid":false,"given":"Zhiyong","family":"Yuan","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer Tianjin's Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy Tianjin 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