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Placental vascular tone is essential for maintaining adequate placental blood flow. Oxytocin is increased in placental system at late pregnancy and onset of labour, and presented strongly concentration\u2010dependent contractions in placental vascular, suggesting that oxytocin could be involved in regulating placental vascular tone and circulation. However, information about the reactivity of oxytocin in pre\u2010eclamptic placental vasculature is limited. This study used a large number of human placentas to reveal the pathophysiological changes and its underlying mechanisms of oxytocin\u2010induced vasoconstrictions in placental vessels under pre\u2010eclamptic condition. Present study found that oxytocin\u2010induced contractions were significantly decreased in human pre\u2010eclamptic placental vasculature, associated with a deactivated transcription of <jats:italic>oxytocin receptor <\/jats:italic>gene. The deactivated <jats:italic>oxytocin receptor <\/jats:italic>gene transcription was ascribed to a relatively higher DNA methylation status of CpG islands in <jats:italic>oxytocin receptor<\/jats:italic> gene promoter. This study was first to reveal that a hyper\u2010methylation of CpG islands in <jats:italic>oxytocin receptor<\/jats:italic> gene promoter, leading to a relatively low pattern of oxytocin receptor expression, was responsible for the decreased sensitivity of oxytocin in pre\u2010eclamptic placental vessels.<\/jats:p>","DOI":"10.1111\/jcmm.14299","type":"journal-article","created":{"date-parts":[[2019,4,5]],"date-time":"2019-04-05T23:01:58Z","timestamp":1554505318000},"page":"4118-4126","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["DNA methylation\u2010reprogrammed oxytocin receptor underlies insensitivity to oxytocin in pre\u2010eclamptic placental vasculature"],"prefix":"10.1111","volume":"23","author":[{"given":"Xiaorong","family":"Fan","sequence":"first","affiliation":[{"name":"Institute for Fetology and Department of Obstetrics and Gynecology First Hospital of Soochow University Suzhou 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