{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T02:32:15Z","timestamp":1792549935366,"version":"4.5.0"},"reference-count":47,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2018,12,26]],"date-time":"2018-12-26T00:00:00Z","timestamp":1545782400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003453","name":"Natural Science Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2015A030310076"],"award-info":[{"award-number":["2015A030310076"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cellular Molecular Medi"],"published-print":{"date-parts":[[2019,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Rutaecarpine attenuates hypertensive cardiac hypertrophy in the rats with abdominal artery constriction (AAC); however, its mechanism of action remains largely unknown. Our previous study indicated that NADPH oxidase 4 (Nox4) promotes angiotensin II (Ang II)\u2010induced cardiac hypertrophy through the pathway between reactive oxygen species (ROS) and a disintegrin and metalloproteinase\u201017 (ADAM17) in primary cardiomyocytes. This research aimed to determine whether the Nox4\u2010ROS\u2010ADAM17 pathway is involved in the protective action of rutaecarpine against hypertensive cardiac hypertrophy. AAC\u2010induced hypertensive rats were adopted to evaluate the role of rutaecarpine in hypertensive cardiac hypertrophy. Western blotting and real\u2010time PCR were used to detect gene expression. Rutaecarpine inhibited hypertensive cardiac hypertrophy in AAC\u2010induced hypertensive rats. These findings were confirmed by the results of in vitro experiments that rutaecarpine significantly inhibited Ang II\u2010induced cardiac hypertrophy in primary cardiomyocytes. Likewise, rutaecarpine significantly suppressed the Nox4\u2010ROS\u2010ADAM17 pathway and over\u2010activation of extracellular signal\u2010regulated kinase (ERK) 1\/2 pathway in the left ventricle of AAC\u2010induced hypertensive rats and primary cardiomyocytes stimulated with Ang II. The inhibition of Nox4\u2010ROS\u2010ADAM17 pathway and over\u2010activation of ERK1\/2 might be associated with the beneficial role of rutaecarpine in hypertensive cardiac hypertrophy, thus providing additional evidence for preventing hypertensive cardiac hypertrophy with rutaecarpine.<\/jats:p>","DOI":"10.1111\/jcmm.14308","type":"journal-article","created":{"date-parts":[[2019,4,6]],"date-time":"2019-04-06T11:03:06Z","timestamp":1554548586000},"page":"4196-4207","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Rutaecarpine prevents hypertensive cardiac hypertrophy involving the inhibition of Nox4\u2010ROS\u2010ADAM17 pathway"],"prefix":"10.1111","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1185-2658","authenticated-orcid":false,"given":"Si\u2010yu","family":"Zeng","sequence":"first","affiliation":[{"name":"Department of Drug Clinical Trial Guangdong Second Provincial General Hospital Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Yang","sequence":"additional","affiliation":[{"name":"Laboratory of Vascular Biology, Institute of Pharmacy and Pharmacology University of South China Hengyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui\u2010qin","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Drug Clinical Trial Guangdong Second Provincial General Hospital Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiu\u2010jiang","family":"Yan","sequence":"additional","affiliation":[{"name":"Department of Cardiac &amp; Thoracic Surgery The Third Affiliated Hospital of Guangzhou Medical University Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Guangdong Second Provincial General Hospital Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xu\u2010ping","family":"Qin","sequence":"additional","affiliation":[{"name":"Laboratory of Vascular Biology, Institute of Pharmacy and Pharmacology University of South China Hengyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,4,5]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(99)00630-0"},{"issue":"8","key":"e_1_2_8_3_1","first-page":"605","article-title":"Studies on the chemical constituents of Evodia rutaecarpa (Juss.). Benth","volume":"39","author":"Wang QZ","year":"2004","journal-title":"Yao Xue Xue Bao"},{"issue":"3","key":"e_1_2_8_4_1","first-page":"1016","article-title":"The vasorelaxing action of rutaecarpine: direct paradoxical effects on intracellular calcium concentration of vascular smooth muscle and endothelial cells","volume":"276","author":"Wang GJ","year":"1996","journal-title":"J Pharmacol Exp Ther"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.regpep.2004.08.001"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004872-200409000-00028"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/bdd.634"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/FJC.0b013e3181579e7e"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1681.2008.05079.x"},{"issue":"4","key":"e_1_2_8_10_1","first-page":"119","article-title":"Rutaecarpine ameliorates pressure overload\u2010induced left cardiac structure changes and function abnormality in rats","volume":"41","author":"Chen H","year":"2018","journal-title":"Journal of Zunyi Medical University"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2003-37703"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cjca.2013.04.026"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2013.03.006"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/7916953"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.3109\/10641963.2012.685534"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.97.19.1952"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.118.008654"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2018.11.077"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.118.010013"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.117.028728"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10616-006-6334-6"},{"issue":"3","key":"e_1_2_8_22_1","first-page":"1237","article-title":"Vasorelaxing action of rutaecarpine: effects of rutaecarpine on calcium channel activities in vascular endothelial and smooth muscle cells","volume":"289","author":"Wang GJ","year":"1999","journal-title":"J Pharmacol Exp Ther"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1139\/Y11-006"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.109.198515"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M113.536847"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mam.2005.07.006"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/19.23.6341"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00395-016-0566-1"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.110.970673"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000099504.30207.F5"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1002178107"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.114.011079"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.112.279760"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1009700107"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(15)60388-9"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.1039703"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200307137"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.116.07620"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.108.127670"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.116.07566"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2016.12.001"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1139\/Y10-067"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(01)01433-4"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1006\/jmcc.2001.1427"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2013.04.038"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M007037200"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.78.6.954"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.110.231514"}],"container-title":["Journal of Cellular and Molecular Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jcmm.14308","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jcmm.14308","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jcmm.14308","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,10]],"date-time":"2023-09-10T19:04:08Z","timestamp":1694372648000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jcmm.14308"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,4,5]]},"references-count":47,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2019,6]]}},"alternative-id":["10.1111\/jcmm.14308"],"URL":"https:\/\/doi.org\/10.1111\/jcmm.14308","archive":["Portico"],"relation":{},"ISSN":["1582-1838","1582-4934"],"issn-type":[{"value":"1582-1838","type":"print"},{"value":"1582-4934","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,4,5]]},"assertion":[{"value":"2018-12-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-03-08","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-04-05","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}