{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T09:17:55Z","timestamp":1762161475313,"version":"3.40.5"},"reference-count":47,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2019,4,11]],"date-time":"2019-04-11T00:00:00Z","timestamp":1554940800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81400512","81570975"],"award-info":[{"award-number":["81400512","81570975"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cellular Molecular Medi"],"published-print":{"date-parts":[[2019,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Oral lichen planus (OLP) is considered a precancerous lesion with no known cure. Recent studies reported that abnormal regulation of apoptosis was involved in the pathogenesis of OLP. Next generation sequencing was used to screen the candidate microRNAs and genes in biopsies from patients with OLP and healthy mucosa. Human oral keratinocytes were transfected into the related oligonucleotides of miR\u201027b\u20103p\/cyclophilin D and their control groups. Apoptosis was detected by TdT\u2010mediated dUTP nick end labelling and flow cytometry. The levels of mRNA and protein were detected by quantitative PCR, Western blots, and enzyme\u2010linked immunosorbent assays, respectively. Luciferase assays were performed to detect the luciferase activities of miR\u201027b\u20103p and cyclophilin D. Here, we showed that basal epithelium apoptosis was reduced and the miR\u201027b\u20103p levels were decreased in clinical OLP samples. We also found that down\u2010regulation of miR\u201027b\u20103p inhibited epithelial keratinocyte apoptosis by up\u2010regulating cyclophilin D expression. Moreover, cyclophilin D increased the protein stability of Bcl2 through direct binding, and Bcl2 suppressed caspase9\/3 activation and cytochrome C release. Taken together, these data showed that miR\u201027b\u20103p regulated keratinocyte apoptosis through cyclophilin D\/Bcl2 signalling, suggesting the miR\u201027b\u20103p regulated the pathogenesis of OLP.<\/jats:p>","DOI":"10.1111\/jcmm.14324","type":"journal-article","created":{"date-parts":[[2019,4,12]],"date-time":"2019-04-12T02:32:45Z","timestamp":1555036365000},"page":"4326-4337","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Down\u2010regulation of miRNA\u201027b\u20103p suppresses keratinocytes apoptosis in oral lichen planus"],"prefix":"10.1111","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7968-7471","authenticated-orcid":false,"given":"Junjun","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Oral Medicine Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine Shanghai China"},{"name":"Department of Biochemistry &amp; Molecular Cell 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