{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T20:09:43Z","timestamp":1776283783316,"version":"3.50.1"},"reference-count":45,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2019,4,16]],"date-time":"2019-04-16T00:00:00Z","timestamp":1555372800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81671464"],"award-info":[{"award-number":["81671464"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cellular Molecular Medi"],"published-print":{"date-parts":[[2019,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Selective intrauterine growth restriction (sIUGR), which affects approximately 10%\u201015% of monochorionic (MC) twin pregnancies, is highly associated with intrauterine foetal death and neurological impairment in both twins. Data suggest that unequal sharing of the single placenta is the main contributor to birth weight discordance. While MC twins and their placenta derive from a single zygote and harbour almost identical genetic material, the underlying mechanisms of phenotypic discrepancies in MC twins remain unclear. MicroRNAs are small non\u2010coding RNA molecules that regulate gene expression but do not change the DNA sequence. Our preliminary study showed that microRNA\u2010210\u20103p (miR\u2010210\u20103p) was significantly upregulated in the placental share of the smaller sIUGR twin. Here, we investigate the potential role of miR\u2010210\u20103p in placental dysplasia, which generally results from dysfunction of trophoblast cells. Functional analysis revealed that miR\u2010210\u20103p, induced by hypoxia\u2010inducible factor 1\u03b1 (HIF1\u03b1) under hypoxic conditions, suppressed the proliferation and invasiveness of trophoblast cell lines. Further RNA sequencing analysis and luciferase reporter assays were performed, revealing that fibroblast growth factor 1 (FGF1) is an influential target gene of miR\u2010210\u20103p. Moreover, correlations among miR\u2010210\u20103p levels, HIF1\u03b1 and FGF1 expression and the smaller placental share were validated in sIUGR specimens. These findings suggest that upregulation of miR\u2010210\u20103p may contribute to impaired placentation of the smaller twin by decreasing FGF1 expression in sIUGR.<\/jats:p>","DOI":"10.1111\/jcmm.14335","type":"journal-article","created":{"date-parts":[[2019,4,17]],"date-time":"2019-04-17T04:58:50Z","timestamp":1555477130000},"page":"4422-4433","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":49,"title":["miRNA\u2010210\u20103p regulates trophoblast proliferation and invasiveness through fibroblast growth factor 1 in selective intrauterine growth restriction"],"prefix":"10.1111","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8974-4636","authenticated-orcid":false,"given":"Lin","family":"Li","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, Fetal Medicine Center The First Affiliated Hospital of Sun Yat\u2010sen University Guangzhou Guangdong 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