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Serum uric acid (SUA) is an important predictor of stroke and atherosclerosis; however, which is supported by few direct evidence based on cohort studies. A prospective cohort study including 2644 North Chinese adults aged \u226540\u00a0years was performed in 2010\u20102012 to investigate the association between SUA and multiterritorial vascular stenosis. Hyperuricaemia was defined as SUA levels &gt;6 and &gt;7\u00a0mg\/dL for males and females, respectively. All participants underwent twice transcranial Doppler (TCD) and bilateral carotid duplex ultrasound to evaluate intracranial artery stenosis (ICAS) and extracranial arterial stenosis (ECAS) and peripheral arterial disease (PAD) was determined by ankle\u2010brachial index (ABI) on January 2010 and January 2012 based on regular health check\u2010ups. The cumulative incidence of vascular stenosis was significantly higher in subjects with hyperuricaemia than in those without hyperuricaemia (54.1% vs. 34.7%, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001). The adjusted odds ratios (ORs) with 95% confidence intervals (CIs) for new on\u2010set vascular stenosis due to hyperuricaemia and a 1\u2010mg\/dL change in SUA level were 1.75 (1.32\u20102.31) and 1.29 (1.21\u20101.38), respectively. Furthermore, in the gender\u2010stratified analysis, the association between SUA levels and ICAS was statistically significant in males (OR: 2.02; 95% CI: 1.18\u20103.46), but not females (OR: 0.85, 95% CI: 0.41\u20101.76, <jats:italic>P<\/jats:italic> for interaction: 0.026).<\/jats:p>","DOI":"10.1111\/jcmm.14337","type":"journal-article","created":{"date-parts":[[2019,6,26]],"date-time":"2019-06-26T08:25:56Z","timestamp":1561537556000},"page":"4970-4979","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Longitudinal association between serum uric acid levels and multiterritorial atherosclerosis"],"prefix":"10.1111","volume":"23","author":[{"given":"Meiyue","family":"Song","sequence":"first","affiliation":[{"name":"Beijing University of Chinese Medicine and China\u2010Japan Friendship Hospital Beijing 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