{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,11]],"date-time":"2025-12-11T20:15:52Z","timestamp":1765484152252,"version":"3.40.5"},"reference-count":46,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2019,4,16]],"date-time":"2019-04-16T00:00:00Z","timestamp":1555372800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81770841"],"award-info":[{"award-number":["81770841"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010854","name":"Jiangsu Provincial Commission of Health and Family Planning","doi-asserted-by":"publisher","award":["H201522"],"award-info":[{"award-number":["H201522"]}],"id":[{"id":"10.13039\/501100010854","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cellular Molecular Medi"],"published-print":{"date-parts":[[2019,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Salidroside is a major phenylethanoid glycoside in <jats:italic>Rhodiola rosea<\/jats:italic> L., a traditional Chinese medicine, with multiple biological activities. It has been shown that salidroside possesses protective effects for alleviating diabetic renal dysfunction, contrast\u2010induced\u2010nephropathy and other kidney diseases. However, the involved molecular mechanism was still not understood well. Herein, we examined the protective effects of salidroside in mice with Adriamycin (ADR)\u2010induced nephropathy and the underlying molecular mechanism. The results showed that salidroside treatment ameliorates proteinuria; improves expressions of nephrin and podocin; and reduces kidney fibrosis and glomerulosclerosis induced by ADR. Mechanistically, ADR induces a robust accumulation of \u03b2\u2010catenin in the nucleus and stimulates its downstream target gene expression. The application of salidroside largely abolishes the nuclear translocation of \u03b2\u2010catenin and thus inhibits its activity. Furthermore, the activation of \u03b2\u2010catenin almost completely counteracts the protective roles of salidroside in ADR\u2010injured podocytes. Taken together, our data indicate that salidroside ameliorates proteinuria, renal fibrosis and podocyte injury in ADR nephropathy, which may rely on inhibition of \u03b2\u2010catenin signalling pathway.<\/jats:p>","DOI":"10.1111\/jcmm.14340","type":"journal-article","created":{"date-parts":[[2019,4,17]],"date-time":"2019-04-17T04:59:07Z","timestamp":1555477147000},"page":"4443-4453","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Salidroside ameliorates Adriamycin nephropathy in mice by inhibiting \u03b2\u2010catenin activity"],"prefix":"10.1111","volume":"23","author":[{"given":"Xinzhong","family":"Huang","sequence":"first","affiliation":[{"name":"Department of Nephrology Affiliated Hospital of Nantong University Nantong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haiyan","family":"Xue","sequence":"additional","affiliation":[{"name":"Department of Nephrology Affiliated Hospital of Nantong University Nantong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinyu","family":"Ma","sequence":"additional","affiliation":[{"name":"Key Laboratory for Neuroregeneration of Jiangsu Province and Ministry of Education Nantong University Nantong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yunzhong","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Medicine Nantong University Nantong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Zhang","sequence":"additional","affiliation":[{"name":"Key Laboratory for Neuroregeneration of Jiangsu Province and Ministry of Education Nantong University Nantong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yue","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Nephrology Traditional Chinese Medicine Hospital of Tongzhou District Nantong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaogang","family":"Qin","sequence":"additional","affiliation":[{"name":"Department of Nephrology Traditional Chinese Medicine Hospital of Tongzhou District Nantong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8411-4619","authenticated-orcid":false,"given":"Cheng","family":"Sun","sequence":"additional","affiliation":[{"name":"Key Laboratory for Neuroregeneration of Jiangsu Province and Ministry of Education Nantong University Nantong China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,4,16]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2014.196"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2009121236"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-med-050311-163340"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1159\/000324943"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2009010019"},{"key":"e_1_2_7_7_1","first-page":"7169547","article-title":"Moxibustion alleviates injury in a rat focal segmental glomerulosclerosis model","volume":"2017","author":"Li Y","year":"2017","journal-title":"Evid Based Complement Alternat Med"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jafc.5b03474"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2015.07.031"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2008.07.051"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep25399"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11010-011-0815-4"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2015.12.007"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jafc.8b01307"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2010.02.002"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules16129912"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00391.2015"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.13120"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ceb.2008.01.009"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2007.12.011"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2012.173"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2015040449"},{"key":"e_1_2_7_23_1","article-title":"Resveratrol ameliorates podocyte damage in diabetic mice via SIRT1\/PGC\u20101alpha mediated attenuation of mitochondrial oxidative stress","author":"Zhang T","year":"2018","journal-title":"J Cell Physiol"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diff.2012.06.004"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.19.8.5696"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.2000.00342.x"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2006050520"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-003-1099-3"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2006010033"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2017.08.004"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2014.11.029"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.90421.2008"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2008060566"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1038\/labinvest.2017.69"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfq076"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ASN.0000089564.55411.7F"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1111\/bcp.12104"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-06844-2"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/3054145"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1081068"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2017.05.016"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2012.05.012"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrneph.2015.88"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2014100989"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.3892\/ijmm.2015.2259"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2014010085"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.1159\/000489365"}],"container-title":["Journal of Cellular and Molecular Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jcmm.14340","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jcmm.14340","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jcmm.14340","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,10]],"date-time":"2023-09-10T19:04:29Z","timestamp":1694372669000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jcmm.14340"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,4,16]]},"references-count":46,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2019,6]]}},"alternative-id":["10.1111\/jcmm.14340"],"URL":"https:\/\/doi.org\/10.1111\/jcmm.14340","archive":["Portico"],"relation":{},"ISSN":["1582-1838","1582-4934"],"issn-type":[{"type":"print","value":"1582-1838"},{"type":"electronic","value":"1582-4934"}],"subject":[],"published":{"date-parts":[[2019,4,16]]},"assertion":[{"value":"2018-11-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-04-01","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-04-16","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}