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Long non\u2010coding RNAs have previously been demonstrated to play important roles in regulating human diseases, particularly cancer. However, the biological functions and molecular mechanisms of long non\u2010coding RNAs in EEC have not been extensively studied. Here, we describe the discovery of Lnc\u2010NA from the promoter of the transcription factor nuclear receptor subfamily 4 group A member 1 (NR4A1) gene. The role and function of Lnc\u2010NA in EEC remain unknown. In this study, we used quantitative real\u2010time polymerase chain reactions to confirm that Lnc\u2010NA expression was down\u2010regulated in 30 EEC cases (90%) and in EEC cell lines compared with that in the paired adjacent tissues and normal endometrial cells. In vitro experiments further demonstrated that overexpressing Lnc\u2010NA decreased EEC cell proliferation, migration and invasion and promoted apoptosis via inactivation of the apoptosis signalling pathway. Moreover, the results show that Lnc\u2010NA expression was positively correlated with NR4A1. Furthermore, Lnc\u2010NA regulated NR4A1 expression and activated the apoptosis signalling pathway to inhibit tumour progression. In summary, our results demonstrate that the Lnc\u2010NA\u2010NR4A1 axis could be a useful tumour suppressor and a promising therapeutic target for EEC.<\/jats:p>","DOI":"10.1111\/jcmm.14345","type":"journal-article","created":{"date-parts":[[2019,5,3]],"date-time":"2019-05-03T07:40:12Z","timestamp":1556869212000},"page":"4699-4710","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Lnc\u2010NA inhibits proliferation and metastasis in endometrioid endometrial carcinoma through regulation of NR4A1"],"prefix":"10.1111","volume":"23","author":[{"given":"Linying","family":"Sun","sequence":"first","affiliation":[{"name":"Department of Central Lab Shandong Provincial Hospital affiliated with Shandong University Jinan China"},{"name":"Institute of Public Health Taishan Medical University Taian 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