{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T17:47:31Z","timestamp":1792691251329,"version":"4.5.0"},"reference-count":58,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2019,4,29]],"date-time":"2019-04-29T00:00:00Z","timestamp":1556496000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81874387"],"award-info":[{"award-number":["81874387"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cellular Molecular Medi"],"published-print":{"date-parts":[[2019,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The traditional Chinese herb <jats:italic>Lonicerae Japonicae Flos<\/jats:italic> has shown significant clinical benefits in the treatment of heart failure, but the mechanism remains unclear. As the main active ingredient found in the plasma after oral administration of <jats:italic>Lonicerae Japonicae Flos<\/jats:italic>, chlorogenic acid (CGA) has been reported to possess anti\u2010inflammatory, anti\u2010oxidant and anti\u2010apoptosis function. We firstly confirmed the cardioprotective effects of CGA in transverse aortic constriction (TAC)\u2010induced heart failure mouse model, through mitigating the TNF\u2010\u03b1\u2013induced toxicity. We further used TNF\u2010\u03b1\u2010induced cardiac injury in human induced pluripotent stem cell\u2010derived cardiomyocytes (hiPSC\u2010CMs) to elucidate the underlying mechanisms. CGA pre\u2010treatment could reverse TNF\u2010\u03b1\u2013induced cellular injuries, including improved cell viability, increased mitochondrial membrane potential and inhibited cardiomyocytes apoptosis. We then examined the NF\u2010\u03baB\/p65 and major mitogen\u2010activated protein kinases (MAPKs) signalling pathways involved in TNF\u2010\u03b1\u2013induced apoptosis of hiPSC\u2010CMs. Importantly, CGA can directly inhibit NF\u2010\u03baB signal by suppressing the phosphorylation of NF\u2010\u03baB\/p65. As for the MAPKs, CGA suppressed the activity of only c\u2010Jun N\u2010terminal kinase (JNK), but enhanced extracellular signal\u2010regulated kinase1\/2 (ERK1\/2) and had no effect on p38. In summary, our study revealed that CGA has profound cardioprotective effects through inhibiting the activation of NF\u2010\u03baB and JNK pathway, providing a novel therapeutic alternative for prevention and treatment of heart failure.<\/jats:p>","DOI":"10.1111\/jcmm.14351","type":"journal-article","created":{"date-parts":[[2019,4,30]],"date-time":"2019-04-30T15:44:41Z","timestamp":1556639081000},"page":"4666-4678","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":67,"title":["Chlorogenic acid: A potent molecule that protects cardiomyocytes from TNF\u2010\u03b1\u2013induced injury via inhibiting NF\u2010\u03baB and JNK signals"],"prefix":"10.1111","volume":"23","author":[{"given":"Lei","family":"Tian","sequence":"first","affiliation":[{"name":"School of Traditional Chinese Medicine Beijing University of Chinese Medicine Beijing 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