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Typhimurium) is closely associated with the\n                    <jats:italic>Salmonella<\/jats:italic>\n                    pathogenicity island (SPI)\u2010encoded type \u2162 secretion system (T3SS), which can directly inject a series of effector proteins into eukaryotic cells to enable bacterial infection. In this study, syringaldehyde was identified as an effective inhibitor of the\n                    <jats:italic>S<\/jats:italic>\n                    . Typhimurium T3SS using an effector protein\u2010lactamase fusion reporter system. Syringaldehyde treatment could inhibit the expression of important effector proteins (SipA, SipB and SipC) at a concentration of 0.18\u00a0mM without affecting bacterial growth. Additionally, significant inhibition of bacterial invasion and cellular injury was observed following the syringaldehyde treatment in the co\u2010infection system of HeLa cells and\n                    <jats:italic>S<\/jats:italic>\n                    . Typhimurium. Furthermore, treatment with syringaldehyde provided systemic protection to mice infected with\n                    <jats:italic>S<\/jats:italic>\n                    . Typhimurium, reducing mortality (40.00%) and bacterial loads and relieving caecal damage and systemic inflammation. The results presented in this study indicate that syringaldehyde significantly affects T3SS activity and is a potential leading compound for treating\n                    <jats:italic>S<\/jats:italic>\n                    . Typhimurium infections.\n                  <\/jats:p>","DOI":"10.1111\/jcmm.14354","type":"journal-article","created":{"date-parts":[[2019,5,8]],"date-time":"2019-05-08T05:33:32Z","timestamp":1557293612000},"page":"4679-4688","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Inhibition of the type III secretion system by syringaldehyde protects mice from\n                    <i>Salmonella enterica<\/i>\n                    serovar Typhimurium"],"prefix":"10.1111","volume":"23","author":[{"given":"Qianghua","family":"Lv","sequence":"first","affiliation":[{"name":"Department of Respiratory Medicine First Hospital, Jilin University Changchun China"},{"name":"Key Laboratory of Zoonosis Research, Ministry of Education, College of Veterinary Medicine, Institute of Zoonosis Jilin University Changchun 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