{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T06:09:21Z","timestamp":1787724561309,"version":"build-2784847793"},"reference-count":49,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2019,5,29]],"date-time":"2019-05-29T00:00:00Z","timestamp":1559088000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cellular Molecular Medi"],"published-print":{"date-parts":[[2019,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>In the central nervous system, interleukin (IL)\u20101\u03b2, IL\u20106 and tumour necrosis factor (TNF)\u2010\u03b1 have a regulatory role in pathophysiological processes of epilepsy. In addition, \u03b3\u2010aminobutyric acid (GABA) transporter type 1 and type 3 (GAT\u20101 and GAT\u20103) modulate the levels of extracellular GABA in involvement in the neuroinflammation on epileptogenesis. Thus, in the current report we examined the effects of inhibiting microRNA\u2010155 (miR\u2010155) on the levels of IL\u20101\u03b2, IL\u20106 and TNF\u2010\u03b1, and expression of GAT\u20101 and GAT\u20103 in the parietal cortex, hippocampus and amygdala of rats with nonconvulsive seizure (NCS) following cerebral ischaemia. Real time RT\u2010PCR, ELISA and Western blot analysis were used to examine the miR\u2010155, proinflammatory cytokines (PICs) and GAT\u20101\/GAT\u20103 respectively. With induction of NCS, the levels of miR\u2010155 were amplified in the parietal cortex, hippocampus and amygdala and this was accompanied with increases of IL\u20101\u03b2, IL\u20106 and TNF\u2010\u03b1. In those central areas, expression of GAT\u20101 and GAT\u20103 was upregulated; and GABA was reduced in rats following NCS. Intracerebroventricular infusion of miR\u2010155 inhibitor attenuated the elevation of PICs, amplification of GAT\u20101 and GAT\u20103 and impairment of GABA. Furthermore, inhibition of miR\u2010155 decreased the number of NCS events following cerebral ischaemia. Inhibition of miR\u2010155 further improved post\u2010ischaemia\u2010evoked NCS by altering neuroinflammation\u2010GABA signal pathways in the parietal cortex, hippocampus and amygdala. Results suggest the role of miR\u2010155 in regulating post\u2010ischaemic seizures via PICs\u2010GABA mechanisms.<\/jats:p>","DOI":"10.1111\/jcmm.14358","type":"journal-article","created":{"date-parts":[[2019,5,30]],"date-time":"2019-05-30T04:20:50Z","timestamp":1559190050000},"page":"5017-5024","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Role of microRNA\u2010155 in modifying neuroinflammation and \u03b3\u2010aminobutyric acid transporters in specific central regions after post\u2010ischaemic seizures"],"prefix":"10.1111","volume":"23","author":[{"given":"Wenwen","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Anesthesiology The First Hospital of Jilin University Changchun Jilin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luping","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology School and Hospital of Stomatology, 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