{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T16:36:56Z","timestamp":1792427816329,"version":"4.5.0"},"reference-count":26,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2019,4,30]],"date-time":"2019-04-30T00:00:00Z","timestamp":1556582400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004733","name":"Universidade de Macau","doi-asserted-by":"publisher","award":["MYRG2018-0161-FHS"],"award-info":[{"award-number":["MYRG2018-0161-FHS"]}],"id":[{"id":"10.13039\/501100004733","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006469","name":"Fundo para o Desenvolvimento das Ci\u00eancias e da Tecnologia","doi-asserted-by":"publisher","award":["101\/2015\/A3"],"award-info":[{"award-number":["101\/2015\/A3"]}],"id":[{"id":"10.13039\/501100006469","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81671689"],"award-info":[{"award-number":["81671689"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cellular Molecular Medi"],"published-print":{"date-parts":[[2019,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Although invasive epithelial ovarian cancer (IOC) and low malignant potential ovarian tumour (LMP) are similar, they are associated with different outcomes and treatment strategies. The current accuracy in distinguishing these diseases is unsatisfactory, leading to delays or unnecessary treatments. We compared the molecular signature of IOC and LMP cases by analysing their transcriptomic data and re\u2010clustered them according to these data rather than the pathological dissection. We identified that FAM83D was highly expressed in IOC. To verify the role of FAM83D in the progression and metastasis, we used the isogenic ovarian cancer metastatic models, highly metastatic cells (HM) and non\u2010metastatic cells (NM). Overexpression of FAM83D significantly promoted cell proliferation, migration and spheroid formation. This was consistent with previous data showing that high FAM83D expression is associated with poor prognosis in cancer patients. Moreover, similar to the HM cells, the FAM83D\u2010overexpressing NM cells demonstrated stronger phosphorylation of the epidermal growth factor receptor (EGFR) and c\u2010Raf. This indicates that the action of FAM83D is mediated by the activation of the EGFR pathway. Taken together, this report suggested that FAM83D might be an excellent molecular marker to discriminate between IOC and LMP.<\/jats:p>","DOI":"10.1111\/jcmm.14360","type":"journal-article","created":{"date-parts":[[2019,5,1]],"date-time":"2019-05-01T02:31:52Z","timestamp":1556677912000},"page":"4569-4581","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["FAM83D promotes ovarian cancer progression and its potential application in diagnosis of invasive ovarian cancer"],"prefix":"10.1111","volume":"23","author":[{"given":"Qingyu","family":"Zhang","sequence":"first","affiliation":[{"name":"Centre of Reproduction, Development and Aging, Faculty of Health Sciences University of Macau Macau China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shan","family":"Yu","sequence":"additional","affiliation":[{"name":"Centre of Reproduction, Development and Aging, Faculty of Health Sciences University of Macau Macau China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samson Ian Sam","family":"Lok","sequence":"additional","affiliation":[{"name":"Centre of Reproduction, Development and Aging, Faculty of Health Sciences University of Macau Macau China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alice Sze Tsai","family":"Wong","sequence":"additional","affiliation":[{"name":"School of Biological Sciences The University of Hong Kong Hong Kong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yufei","family":"Jiao","sequence":"additional","affiliation":[{"name":"Department of Pathology The Second Affiliated Hospital of Harbin Medical University Harbin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3691-478X","authenticated-orcid":false,"given":"Leo Tsz On","family":"Lee","sequence":"additional","affiliation":[{"name":"Centre of Reproduction, Development and Aging, Faculty of Health 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