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Extensive research focus on endoplasmic reticulum (ER) stress and its dysfunction which leads to cardiac injury in MI\/R Our study evaluated the effects of sulodexide (SDX) on MI\/R by establishing MI\/R mice models and in vitro oxidative stress models in H9C2 cells. We found that SDX decreases cardiac injury during ischaemia reperfusion and decreased myocardial apoptosis and infarct area, which was paralleled by increased superoxide dismutase and reduced malondialdehyde in mice plasm, increased Bcl\u20102 expression, decreased BAX expression in a mouse model of MI\/R. In vitro, SDX exerted a protective effect by the suppression of the ER stress which induced by tert\u2010butyl hydroperoxide (TBHP) treatment. Both of the in vivo and in vitro effects were involved in the phosphatidylinositol 3\u2010kinase (PI3K)\/Akt signalling pathway. Inhibition of PI3K\/Akt pathway by specific inhibitor, LY294002, partially reduced the protective effect of SDX. In short, our results suggested that the cardioprotective role of SDX was related to the suppression of ER stress in mice MI\/R models and TBHP\u2010induced H9C2 cell injury which was through the PI3K\/Akt signalling pathway.<\/jats:p>","DOI":"10.1111\/jcmm.14367","type":"journal-article","created":{"date-parts":[[2019,5,23]],"date-time":"2019-05-23T11:14:10Z","timestamp":1558610050000},"page":"5063-5075","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":35,"title":["Sulodexide attenuates endoplasmic reticulum stress induced by myocardial ischaemia\/reperfusion by activating the PI3K\/Akt pathway"],"prefix":"10.1111","volume":"23","author":[{"given":"Danping","family":"Shen","sequence":"first","affiliation":[{"name":"Children's Heart Center Institute of Cardiovascular Development and Translational Medicine, The Second Affiliated Hospital &amp; Yuying Children's Hospital of Wenzhou Medical University Wenzhou Zhejiang 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