{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T18:06:13Z","timestamp":1792087573196,"version":"4.4.0"},"reference-count":37,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2019,7,14]],"date-time":"2019-07-14T00:00:00Z","timestamp":1563062400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cellular Molecular Medi"],"published-print":{"date-parts":[[2019,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Thyroid cancer (TC) is a prevalent endocrine malignant cancer whose pathogenic mechanism remains unclear. The aim of the study was to investigate the roles of long non\u2010coding RNA (lncRNA) NR2F1\u2010AS1\/miRNA\u2010338\u20103P\/<jats:italic>CCND1<\/jats:italic>axis in TC progression. Differentially expressed lncRNAs and mRNAs in TC tissues were screened out and visualized by R program. Relative expression of NR2F1\u2010AS1, miRNA\u2010338\u20103p and cyclin D1 (<jats:italic>CCND1<\/jats:italic>) was determined by quantitative real time polymerase chain reaction. In addition, Western blot analysis was adopted for evaluation of protein expression of<jats:italic>CCND1<\/jats:italic>. Targeted relationships between NR2F1\u2010AS1 and miRNA\u2010338\u20103p, as well as miRNA\u2010338\u20103p and<jats:italic>CCND1<\/jats:italic>were predicted using bioinformatics analysis and validated by dual\u2010luciferase reporter gene assay. Besides, tumour xenograft assay was adopted for verification of the role of NR2F1\u2010AS1 in TC in vivo. NR2F1\u2010AS1 and<jats:italic>CCND1<\/jats:italic>were overexpressed, whereas miRNA\u2010338\u20103p was down\u2010regulated in TC tissues and cell lines. Down\u2010regulation of NR2F1\u2010AS1 and<jats:italic>CCND1<\/jats:italic>suppressed proliferation and migration of TC cells yet greatly enhanced cell apoptotic rate. Silence of NR2F1\u2010AS1 significantly suppressed TC tumorigenesis in vivo. NR2F1\u2010AS1 sponged miRNA\u2010338\u20103p to up\u2010regulate<jats:italic>CCND1<\/jats:italic>expression to promote TC progression. Our study demonstrated that up\u2010regulation of NR2F1\u2010AS1 accelerated TC progression through regulating miRNA\u2010338\u20103P\/<jats:italic>CCND1<\/jats:italic>axis.<\/jats:p>","DOI":"10.1111\/jcmm.14386","type":"journal-article","created":{"date-parts":[[2019,7,15]],"date-time":"2019-07-15T05:26:12Z","timestamp":1563168372000},"page":"5907-5919","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":55,"title":["Long non\u2010coding RNA NR2F1\u2010AS1 promoted proliferation and migration yet suppressed apoptosis of thyroid cancer cells through regulating miRNA\u2010338\u20103p\/<i>CCND1<\/i>axis"],"prefix":"10.1111","volume":"23","author":[{"given":"Feng","family":"Guo","sequence":"first","affiliation":[{"name":"Department of Ultrasound China\u2010Japan Union Hospital of Jilin University Changchun Jilin 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