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The comorbidity may lead to more serious conditions with other symptoms and a longer duration of treatment and it may impose heavy economic and social burdens, directly or indirectly, on patients and their families. Numerous studies have been published on the association of migraine with depression. Numerous literature have showed that the comorbidity may have a common complicated pathogenic mechanism involving biopsychosocial characteristics, including abnormal brain development and shared genetic basis, as well as neurotransmitters, sex hormones and stress. In addition, some studies have identified the multiple, bidirectional relationship between migraine and depressive disorder. We searched the literature for the possible common mechanisms between migraine and depression and classified the research results.<\/jats:p>","DOI":"10.1111\/jcmm.14390","type":"journal-article","created":{"date-parts":[[2019,5,20]],"date-time":"2019-05-20T10:28:54Z","timestamp":1558348134000},"page":"4505-4513","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":87,"title":["The exploration of mechanisms of comorbidity between migraine and depression"],"prefix":"10.1111","volume":"23","author":[{"given":"Qing","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Psychiatry Second Affiliated Hospital, School of Medicine, Zhejiang University Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5616-0394","authenticated-orcid":false,"given":"Anwen","family":"Shao","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Second Affiliated Hospital, School of Medicine, Zhejiang University Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhengyan","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Second Affiliated Hospital, School of Medicine, Zhejiang University Hangzhou China"},{"name":"Department of General Practice Second Affiliated Hospital, School of Medicine, Zhejiang University Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huitzong","family":"Tsai","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Second Affiliated Hospital, School of Medicine, Zhejiang University Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weibo","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Second Affiliated Hospital, School of Medicine, Zhejiang University Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,5,20]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-2982.2007.01288.x"},{"issue":"4","key":"e_1_2_12_3_1","first-page":"288","article-title":"Shared genetic factors in migraine and depression","volume":"74","author":"Stam AH","year":"2010","journal-title":"Evidence from a genetic isolate. 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