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However, currently no specific therapies have been reported for t (8;21) AML patients as AML1\u2010ETO is still intractable as a pharmacological target. For this purpose, leukaemia cells and AML1\u2010ETO\u2010induced murine leukaemia model were used to investigate the degradation of AML1\u2010ETO by melatonin (MLT), synthesized and secreted by the pineal gland. MLT remarkedly decreased AML1\u2010ETO protein in leukemic cells. Meanwhile, MLT induced apoptosis, decreased proliferation and reduced colony formation. Furthermore, MLT reduced the expansion of human leukemic cells and extended the overall survival in U937T\u2010AML1\u2010ETO\u2010xenografted NSG mice. Most importantly, MLT reduced the infiltration of leukaemia blasts, decreased the frequency of leukaemia stem cells (LSCs) and prolonged the overall survival in AML1\u2010ETO\u2010induced murine leukaemia. Mechanistically, MLT increased the expression of miR\u2010193a, which inhibited AML1\u2010ETO expression via targeting its putative binding sites. Furthermore, MLT decreased the expression of \u03b2\u2010catenin, which is required for the self\u2010renewal of LSC and is the downstream of AML1\u2010ETO. Thus, MLT presents anti\u2010self\u2010renewal of LSC through miR\u2010193a\u2010AML1\u2010ETO\u2010\u03b2\u2010catenin axis. In conclusion, MLT might be a potential treatment for t (8;21) leukaemia by targeting AML1\u2010ETO oncoprotein.<\/jats:p>","DOI":"10.1111\/jcmm.14399","type":"journal-article","created":{"date-parts":[[2019,5,23]],"date-time":"2019-05-23T14:29:12Z","timestamp":1558621752000},"page":"5246-5258","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Targeting miR\u2010193a\u2010AML1\u2010ETO\u2010\u03b2\u2010catenin axis by melatonin suppresses the self\u2010renewal of leukaemia stem cells in leukaemia with t (8;21) translocation"],"prefix":"10.1111","volume":"23","author":[{"given":"Bin","family":"Zhou","sequence":"first","affiliation":[{"name":"Laboratory of Internal Medicine The First Affiliated Hospital of Wenzhou Medical University Wenzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haige","family":"Ye","sequence":"additional","affiliation":[{"name":"Department of Hematology The First 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