{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T14:06:54Z","timestamp":1778854014602,"version":"3.51.4"},"reference-count":59,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2019,6,24]],"date-time":"2019-06-24T00:00:00Z","timestamp":1561334400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003453","name":"Natural Science Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["#2016A030313634, #2017A030313888"],"award-info":[{"award-number":["#2016A030313634, #2017A030313888"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["#81503394"],"award-info":[{"award-number":["#81503394"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cellular Molecular Medi"],"published-print":{"date-parts":[[2019,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Danqi soft capsule (DQ) is a traditional Chinese medicine containing <jats:italic>Salvia miltiorrhiza<\/jats:italic> and <jats:italic>Panax notoginseng<\/jats:italic>; it is safe and efficient in treating ischaemic heart diseases. The purpose of the present study was to assess whether DQ could prevent infarct border zone (IBZ) remodelling and decrease ventricular arrhythmias occurrence in post\u2010myocardial infarction (MI) stage. MI was induced by a ligation of the left anterior descending coronary artery. DQ was administered to the post\u2010MI rats started from 1\u00a0week after MI surgery for 4\u00a0weeks. The results showed that DQ treatment significantly attenuated tachyarrhythmia induction rates and arrhythmia score in post\u2010MI rats. In echocardiography, DQ improved left ventricular (LV) systolic and diastolic function. Histological assessment revealed that DQ significantly reduced fibrotic areas and myocyte areas, and increased connexin (Cx) 43 positive areas in IBZ. Western blot revealed that DQ treatment significantly reduced the protein expression levels of type I and III collagens, \u03b1\u2010smooth muscle actin (\u03b1\u2010SMA), transforming growth factor\u2010\u03b21 (TGF\u2010\u03b21) and Smad3 phosphorylation, while increasing Cx43 amounts. Overall, these findings mainly indicated that DQ intervention regulates interstitial fibrosis, Cx43 expression and myocyte hypertrophy by TGF\u2010\u03b21\/Smad3 pathway in IBZ, inhibits LV remodelling and reduces vulnerability to tachyarrhythmias after MI. This study presents a proof of concept for novel antiarrhythmic strategies in preventing IBZ remodelling, modifying the healed arrhythmogenic substrate and thus reducing susceptibility to ventricular arrhythmias in the late post\u2010MI period.<\/jats:p>","DOI":"10.1111\/jcmm.14428","type":"journal-article","created":{"date-parts":[[2019,6,25]],"date-time":"2019-06-25T16:36:26Z","timestamp":1561480586000},"page":"5454-5465","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Danqi soft capsule prevents infarct border zone remodelling and reduces susceptibility to ventricular arrhythmias in post\u2010myocardial infarction rats"],"prefix":"10.1111","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3968-584X","authenticated-orcid":false,"given":"Shiyu","family":"Ma","sequence":"first","affiliation":[{"name":"The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangdong Provincial Hospital of Chinese Medicine Guangzhou China"},{"name":"Guangzhou Key Laboratory of Chinese Medicine for Prevention and Treatment of Myocardial Infarction Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin","family":"Ma","sequence":"additional","affiliation":[{"name":"The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangdong Provincial Hospital of Chinese Medicine Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoyi","family":"Mai","sequence":"additional","affiliation":[{"name":"The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangdong Provincial Hospital of Chinese Medicine Guangzhou China"},{"name":"Guangzhou Key Laboratory of Chinese Medicine for Prevention and Treatment of Myocardial Infarction Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xujie","family":"Zhao","sequence":"additional","affiliation":[{"name":"The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangdong Provincial Hospital of Chinese Medicine Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liheng","family":"Guo","sequence":"additional","affiliation":[{"name":"The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangdong Provincial Hospital of Chinese Medicine Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2075-5641","authenticated-orcid":false,"given":"Minzhou","family":"Zhang","sequence":"additional","affiliation":[{"name":"The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangdong Provincial Hospital of Chinese Medicine Guangzhou China"},{"name":"Guangzhou Key Laboratory of Chinese Medicine for Prevention and Treatment of Myocardial Infarction Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,6,24]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamacardio.2018.0016"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccep.2017.08.003"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8159.2010.02704.x"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2010.04.030"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2013.10.018"},{"key":"e_1_2_9_7_1","first-page":"62","article-title":"Cardiac remodeling: concepts, clinical impact, pathophysiological mechanisms and pharmacologic treatment","volume":"106","author":"Azevedo PS","year":"2016","journal-title":"Arq Bras Cardiol"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2010.07.025"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2016.09.054"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12906-016-1083-3"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/1472-6882-14-67"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.108.531616"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1159\/000126919"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.talanta.2005.09.041"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpba.2005.10.023"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0059621"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1186\/2047-783X-18-16"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2016.12.036"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/jce.13448"},{"key":"e_1_2_9_20_1","first-page":"108","article-title":"Myocardial protection effect of Danqi soft capsule and its improving effect on hemorheology in patients with coronary heart disease","volume":"25","author":"Guo X","year":"2016","journal-title":"Chin J Cardiovasc Rehabil Med"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.98.19.2074"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11655-015-2159-5"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.13185"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2018.02.013"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/9469670"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12906-016-1496-z"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2018.00356"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCIMAGING.114.002077"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.106.653568"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00025.2003"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacep.2016.03.007"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCINTERVENTIONS.116.004172"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep40523"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2013.10.023"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2009.05.002"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12265-012-9408-1"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2013.10.019"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd.2016.89"},{"key":"e_1_2_9_39_1","first-page":"2263","article-title":"Simultaneous determination and pharmacokinetics of several components in Danqi soft capsule by UPLC\u2010TQ MS","volume":"37","author":"Cui Y","year":"2018","journal-title":"Lat Am J Pharm"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.12659\/MSM.908936"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1248\/bpb.b16-00046"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1186\/1472-6882-14-415"},{"key":"e_1_2_9_43_1","first-page":"1451","article-title":"Tanshinone IIA protects against cardiac fibrosis through inhibition of beta\u2010tubulin expression","volume":"32","author":"Zhang Y","year":"2018","journal-title":"J Biol Regul Homeost Agents"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2009.02.038"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamcr.2015.10.019"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1002\/cphy.c160046"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.88.3.333"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI115173"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.88.3.864"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.95.4.988"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI119367"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8167.1999.tb00192.x"},{"key":"e_1_2_9_53_1","first-page":"613","article-title":"Effects of doxycycline on cx43 distribution and cardiac arrhythmia susceptibility of rats after myocardial infarction","volume":"13","author":"Fana XZ","year":"2014","journal-title":"Iran J Pharm Res"},{"key":"e_1_2_9_54_1","first-page":"5283","article-title":"Telmisartan reduces arrhythmias through increasing cardiac connexin43 by inhibiting IL\u201017 after myocardial infarction in rats","volume":"21","author":"Chang HY","year":"2017","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"e_1_2_9_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccep.2015.03.017"},{"key":"e_1_2_9_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2012.06.003"},{"key":"e_1_2_9_57_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12350-016-0600-6"},{"key":"e_1_2_9_58_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCEP.114.001471"},{"key":"e_1_2_9_59_1","doi-asserted-by":"publisher","DOI":"10.1113\/expphysiol.1998.sp004157"},{"key":"e_1_2_9_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardiores.2004.04.030"}],"container-title":["Journal of Cellular and Molecular Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjcmm.14428","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jcmm.14428","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jcmm.14428","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jcmm.14428","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,16]],"date-time":"2023-10-16T08:41:25Z","timestamp":1697445685000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jcmm.14428"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,6,24]]},"references-count":59,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2019,8]]}},"alternative-id":["10.1111\/jcmm.14428"],"URL":"https:\/\/doi.org\/10.1111\/jcmm.14428","archive":["Portico"],"relation":{},"ISSN":["1582-1838","1582-4934"],"issn-type":[{"value":"1582-1838","type":"print"},{"value":"1582-4934","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,6,24]]},"assertion":[{"value":"2018-10-31","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-04-19","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-06-24","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}