{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T00:09:48Z","timestamp":1789949388643,"version":"4.0.1"},"reference-count":35,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2019,7,9]],"date-time":"2019-07-09T00:00:00Z","timestamp":1562630400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81702239"],"award-info":[{"award-number":["81702239"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cellular Molecular Medi"],"published-print":{"date-parts":[[2019,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The decline of cell function caused by ageing directly impacts the therapeutic effects of autologous stem cell transplantation for heart repair. The aim of this study was to investigate whether overexpression of neuron\u2010derived neurotrophic factor (NDNF) can rejuvenate the adipose\u2010derived stem cells in the elderly and such rejuvenated stem cells can be used for cardiac repair. Human adipose\u2010derived stem cells (hADSCs) were obtained from donors age ranged from 17 to 92\u00a0years old. The effects of age on the biological characteristics of hADSCs and the expression of ageing\u2010related genes were investigated. The effects of transplantation of NDNF over\u2010expression stem cells on heart repair after myocardial infarction (MI) in adult mice were investigated. The proliferation, migration, adipogenic and osteogenic differentiation of hADSCs inversely correlated with age. The mRNA and protein levels of NDNF were significantly decreased in old (&gt;60\u00a0years old) compared to young hADSCs (&lt;40\u00a0years old). Overexpression of NDNF in old hADSCs significantly improved their proliferation and migration capacity in vitro. Transplantation of NDNF\u2010overexpressing old hADSCs preserved cardiac function through promoting angiogenesis on MI mice. NDNF rejuvenated the cellular function of aged hADSCs. Implantation of NDNF\u2010rejuvenated hADSCs improved angiogenesis and cardiac function in infarcted mouse hearts.<\/jats:p>","DOI":"10.1111\/jcmm.14456","type":"journal-article","created":{"date-parts":[[2019,7,9]],"date-time":"2019-07-09T05:42:47Z","timestamp":1562650967000},"page":"5981-5993","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Effect of neuron\u2010derived neurotrophic factor on rejuvenation of human adipose\u2010derived stem cells for cardiac repair after myocardial infarction"],"prefix":"10.1111","volume":"23","author":[{"given":"Kun","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, Shanxi Key Laboratory of Birth Defect and Cell Regeneration Shanxi Medical University Taiyuan China"},{"name":"Department of Endocrinology Shanxi Dayi Hospital affiliated to Shanxi Medical University Taiyuan 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