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Yellow wine polyphenolic compounds (YWPC), which are full of polyphenols, have beneficial effects on cardiovascular disease. However, their role in DOX\u2010induced cardiotoxicity is poorly understood. Due to their antioxidant property, we have been suggested that YWPC could prevent DOX\u2010induced cardiotoxicity. In this study, we found that YWPC treatment (30\u00a0mg\/kg\/day) significantly improved DOX\u2010induced cardiac hypertrophy and cardiac dysfunction. YWPC alleviated DOX\u2010induced increase in oxidative stress levels, reduction in endogenous antioxidant enzyme activities and inflammatory response. Besides, administration of YWPC could prevent DOX\u2010induced mitochondria\u2010mediated cardiac apoptosis. Mechanistically, we found that YWPC attenuated DOX\u2010induced reactive oxygen species (ROS) and down\u2010regulation of transforming growth factor beta 1 (TGF\u2010\u03b21)\/smad3 pathway by promoting nuclear factor (erythroid\u2010derived 2)\u2010like 2 (Nrf2) nucleus translocation in cultured H9C2 cardiomyocytes. Additionally, YWPC against DOX\u2010induced TGF\u2010\u03b21 up\u2010regulation were abolished by Nrf2 knockdown. Further studies revealed that YWPC could inhibit DOX\u2010induced cardiac fibrosis through inhibiting TGF\u2010\u03b2\/smad3\u2010mediated ECM synthesis. Collectively, our results revealed that YWPC might be effective in mitigating DOX\u2010induced cardiotoxicity by Nrf2\u2010dependent down\u2010regulation of the TGF\u2010\u03b2\/smad3 pathway.<\/jats:p>","DOI":"10.1111\/jcmm.14466","type":"journal-article","created":{"date-parts":[[2019,6,21]],"date-time":"2019-06-21T13:50:33Z","timestamp":1561125033000},"page":"6034-6047","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":58,"title":["Yellow Wine Polyphenolic Compounds prevents Doxorubicin\u2010induced cardiotoxicity through activation of the Nrf2 signalling pathway"],"prefix":"10.1111","volume":"23","author":[{"given":"Hui","family":"Lin","sequence":"first","affiliation":[{"name":"Department of Cardiology Shaoxing People\u2019s Hospital (Shaoxing Hospital, Zhejiang University School of Medicine) Shaoxing China"},{"name":"The First Clinical Medical College Wenzhou Medical University Wenzhou 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